Evidence map›Paper›PMID 40428132›Full record

ReviewBioengineering (Basel, Switzerland)2025

Integrating Artificial Intelligence in Orthopedic Care: Advancements in Bone Care and Future Directions.

Rahul Kumar, Kyle Sporn, Joshua Ong, Ethan Waisberg, Phani Paladugu, Swapna Vaja, Tamer Hage, Tejas C Sekhar, Amar S Vadhera, Alex Ngo and 3 more

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  9. Bone Grafts: Everything You Need to Know.Journal of periodontal research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rahul KumarDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA.ORCID 0000-0001-8574-2895
Kyle SpornNorton College of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA.ORCID 0009-0005-5707-9009
Joshua OngKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.ORCID 0000-0003-4860-827X
Ethan WaisbergDepartment of Clinical Neurosciences, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
Phani PaladuguSidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St, Philadelphia, PA 19107, USA.
Swapna VajaRush Medical College, Chicago, IL 60612, USA.ORCID 0000-0002-4982-3708
Tamer HageDepartment of Biological Sciences at Virginia Tech, Blacksburg, VA 24061, USA.
Tejas C SekharRush Medical College, Chicago, IL 60612, USA.ORCID 0000-0003-0848-8365
Amar S VadheraSidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St, Philadelphia, PA 19107, USA.
Alex NgoDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA.ORCID 0000-0001-7524-6556
Nasif ZamanSmith-Kettlewell Eye Research Institute, San Francisco, CA 94115, USA.ORCID 0000-0003-0120-0939
Alireza TavakkoliHuman-Machine Perception Laboratory, Department of Computer Science and Engineering, University of Nevada, 1664 N Virginia St, Reno, NV 89557, USA.ORCID 0000-0001-9460-1269
Mouayad MasalkhiSchool of Medicine, University College of Dublin, Belfield, D04 V1W8 Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence (AI) is revolutionizing the field of orthopedic bioengineering by increasing diagnostic accuracy and surgical precision and improving patient outcomes. This review highlights using AI for orthopedics in preoperative planning, intraoperative robotics, smart implants, and bone regeneration. AI-powered imaging, automated 3D anatomical modeling, and robotic-assisted surgery have dramatically changed orthopedic practices. AI has improved surgical planning by enhancing complex image interpretation and providing augmented reality guidance to create highly accurate surgical strategies. Intraoperatively, robotic-assisted surgeries enhance accuracy and reduce human error while minimizing invasiveness. AI-powered smart implant sensors allow for in vivo monitoring, early complication detection, and individualized rehabilitation. It has also advanced bone regeneration devices and neuroprosthetics, highlighting its innovation capabilities. While AI advancements in orthopedics are exciting, challenges remain, like the need for standardized surgical system validation protocols, assessing ethical consequences of AI-derived decision-making, and using AI with bioprinting for tissue engineering. Future research should focus on proving the reliability and predictability of the performance of AI-pivoted systems and their adoption within clinical practice. This review synthesizes recent developments and highlights the increasing impact of AI in orthopedic bioengineering and its potential future effectiveness in bone care and beyond.

Indexed as

AIbone regeneration devicesbone tumor managementdiagnostic imaginginteractive 3D modelsintraoperative roboticsorthopedic bioengineeringpreoperative planningsmart implants

Identifiers

PMID40428132
PMCPMC12109427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.