Causal Relationship Between Blood Metabolites and Osteoporosis: A Two-Sample Mendelian Randomization and Genetic Correlation Analysis.

Xu Liu, Guang Yang, Yusheng Li, Wenfeng Xiao, Bangbao Lu, Yaping Wang

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data.Aging cell · 2026
Observational
PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly.Current osteoporosis reports · 2026
Review
Development and validation of a nomogram for osteoporosis based on clinical characteristics in Kunming.Journal of orthopaedic surgery and research · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xu LiuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China.ORCID 0000-0003-3345-0369

Guang YangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China.

Yusheng LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China.

Wenfeng XiaoDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China.

Bangbao LuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China.

Yaping WangDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China.

Funding

Hunan Provincial Science Fund for Distinguished Young Scholars 2024JJ2089National Natural Science Foundation of China 82272611, 82072506, 92268115Natural Science Foundation of Hunan Province 2023JJ30949Science and Technology Innovation Program of Hunan Province 2023SK2024the Hunan Provincial Innovation Foundation for Postgraduate CX20240330the National Key R&D Program of China 2023YFB4606705, 2023YFC3603400

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Mendelian randomizationmetabolitesosteoporosis

Identifiers

PMID40428054

DOI10.3390/bioengineering12050435

PMCPMC12109198

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.