ArticleInternational journal of environmental research and public health2025
Screening with the Bilateral Corneal Symmetry 3-D Analyzer.
Article in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
This study aimed to evaluate the effectiveness of an innovative platform (the Bilateral Corneal Symmetry 3-D Analyzer-BiCSA) and a novel corneal symmetry index (the Volume Between Spheres-VBS) in differentiating normal corneas from those with keratoconus. Pentacam imaging data from 30 healthy corneas and 30 keratoconus cases were analyzed. BiCSA was utilized to determine the VBS for each case. Statistical analyses included comparing mean VBS values between groups and assessing sensitivity, specificity, and positive predictive values (PPVs). Keratoconus patients exhibited significantly higher VBS scores compared to healthy controls, particularly within the central 4.0 mm zone (11.4 versus 6.3). Using a VBS threshold of 11.3 in the central zone identified 40% of keratoconus cases (40% sensitivity), but 100% of cases surpassing the threshold were keratoconus (100% PPV). Lowering the threshold to 10.4 increased case detection to 90% while maintaining a high PPV (84.2%). These findings suggest that VBS, particularly when focused on the central 4.0 mm zone, can be a valuable tool for early keratoconus screening and identifying potential corneal abnormalities requiring further clinical evaluation. No healthy control corneas in this study exceeded a VBS threshold of 11.4 at 4 mm, indicating that values above this warrant further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.