Evidence map›Paper›PMID 40427819›Full record

ReviewInternational journal of environmental research and public health2025

Health Disparities at the Intersection of Racism, Social Determinants of Health, and Downstream Biological Pathways.

Roland J Thorpe, Marino A Bruce, Tanganyika Wilder, Harlan P Jones, Courtney Thomas Tobin, Keith C Norris

Abstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Does Multilingualism Shape Aging Equally Across Populations?Journal of immigrant and minority health · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Weathering the STORM and Forecasting Equity for Older Black Women: Expanding Social Determinants of Health.International journal of environmental research and public health · 2025
    Article
  7. Applying Race and Ethnicity in Health Disparities Research.International journal of environmental research and public health · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roland J ThorpeProgram for Research on Men's Health, Hopkins Center for Health Disparities Solutions, Baltimore, MD 21205, USA.
Marino A BruceFaith, Justice and Health Collaboratory, University of Houston Population Health, University of Houston, Houston, TX 77204, USA.ORCID 0000-0002-0643-1640
Tanganyika WilderSchool of Allied Health Sciences, Division of Health Sciences, Florida A&M University, Tallahassee, FL 32317, USA.
Harlan P JonesDepartment of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Courtney Thomas TobinDepartment of Community Health Sciences, Fielding School of Public Health, University of California, Los Angeles, CA 90995, USA.
Keith C NorrisDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
NIA NIH HHS P30 AG066507NIH HHS U54MD000214, P30AG059298, 5R25HL126145, R03AG089289, 5R25HL126145, UL1TR001881, P30AG021684, U2CDK129496, P50MD017366.
6 · The paper itself

Abstract

Despite overall improvements in the accessibility, quality, and outcomes of care in the U.S. health care system over the last 30 years, a large proportion of marginalized racial and ethnic minority (minoritized) groups continue to suffer from worse outcomes across most domains. Many of these health disparities are driven by inequities in access to and the scope of society's health-affirming structural resources and opportunities commonly referred to as structural drivers or social determinants of health-SDoH. Persistently health-undermining factors in the social environment and the downstream effects of these inequities on neurocognitive and biological pathways exacerbate these disparities. The consequences of these circumstances manifest as behavioral, neurohormonal, immune, and inflammatory and oxidative stress responses, as well as epigenetic changes. We propose a theoretical model of the interdependent characteristics of inequities in the SDoH driven by race-based discriminatory laws, policies, and practices that eventually culminate in poor health outcomes. This model provides a framework for developing and validating multi-level interventions designed to target root causes, thereby lessening health disparities and accelerating improved health outcomes for minoritized groups.

Indexed as

Health Status DisparitiesRacismSocial Determinants of HealthHumansUnited Statesbiological mechanismshealth disparitiesraceracismsocial determinants of healthstressstressorstheoretical frameworks

Identifiers

PMID40427819
PMCPMC12111065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.