Evidence map›Paper›PMID 40427676›Full record

ArticleBiology2025

Deciphering the Regulatory Potential of Antioxidant and Electron-Shuttling Bioactive Compounds in Oolong Tea.

Regineil A Ferrer, Bor-Yann Chen, Jon Patrick T Garcia, Christine Joyce F Rejano, Po-Wei Tsai, Chung-Chuan Hsueh, Lemmuel L Tayo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Regineil A FerrerSchool of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, Manila 1002, Philippines.ORCID 0009-0007-1105-9322
Bor-Yann ChenDepartment of Chemical and Materials Engineering, National I-lan University, I-lan 260, Taiwan.ORCID 0000-0003-4449-2759
Jon Patrick T GarciaSchool of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, Manila 1002, Philippines.ORCID 0009-0001-5081-9263
Christine Joyce F RejanoSchool of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, Manila 1002, Philippines.ORCID 0009-0005-1266-1783
Po-Wei TsaiDepartment of Food Science, National Taiwan Ocean University, Keelung 202, Taiwan.ORCID 0000-0002-1981-5360
Chung-Chuan HsuehDepartment of Chemical and Materials Engineering, National I-lan University, I-lan 260, Taiwan.
Lemmuel L TayoDepartment of Biology, School of Health Sciences, Mapúa University, Makati 1200, Philippines.

Funding

Taiwan's National Science and Technology Council MOST 109-2221-E-197-016-MY3Taiwan's National Science and Technology Council MOST 110-2221-E-197-008Taiwan's National Science and Technology Council NSTC 112-2221-E-197-004-MY3Taiwan's National Science and Technology Council NSTC 113-2221-E-197-001-MY2
6 · The paper itself

Abstract

OT has gained attention for its high polyphenol content and therapeutic potential. To elucidate this further, this study investigated the electron-shuttling bioactive compounds of OT and evaluated their effect on dysregulated breast cancer (BC) genes. OT extracts were obtained via solvent extraction (SE) and supercritical fluid extraction (SFE), followed by in vitro assays. Phytochemical analysis revealed that ethanol-extracted OT (OTL-E) had the highest polyphenol, flavonoid, and tannin contents, correlating with strong antioxidant activity, while water-extracted OT (OTL-W) exhibited greater bioelectricity-stimulating properties in microbial fuel cells (MFC), confirmed by cyclic voltammetry (CV). Based on phytochemical analyses, SE displayed a better extraction technique for isolating OT bioactive compounds compared to SFE. In silico approaches through network pharmacology, molecular docking and dynamics simulations revealed that polyphenols with

Indexed as

antioxidantbreast cancerCVelectron shuttlesflavonoidsin silicoin vitroMFCmolecular dockingmolecular dynamicsnetwork pharmacologyOolong tea

Identifiers

PMID40427676
PMCPMC12109060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.