ReviewBiology2025
Oxidative Stress Biomarkers in Fish Exposed to Environmental Concentrations of Pharmaceutical Pollutants: A Review.
Review in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Climate Change and Contaminants of Emerging Concern: Enrofloxacin Effects on Manila Clam (Ruditapes philippinarum) Under Simulated Ocean Warming.Journal of applied toxicology : JAT · 2026Article
- ZnO nanoparticle-mediated cadmium adsorption induces bioaccumulation, oxidative stress, and apoptotic responses in Korean rockfish Sebastes schlegelii.Fish physiology and biochemistry · 2026Article
- Acute Toxic Impact of Cyclophosphamide on the Metabolic Organs of Siamese Fighting Fish (Toxics · 2026Article
- Emerging Environmental Toxicants Undermine Reproductive Success in Aquatic Animals: A Narrative Review.Journal of xenobiotics · 2026Review
- Article
- Microencapsulated Functional Additives in Commercial Diets: Effects on Growth, Health, and Intestinal Pro-Inflammatory Gene Expression in Juvenile Rainbow Trout (Animals : an open access journal from MDPI · 2026Article
- Laboratory hazard characterization of acute and sub-lethal urea exposure in Nile Tilapia (Oreochromis niloticus).Open veterinary journal · 2026Article
- Review
- The photoacclimation state of stolen chloroplasts affects the light preferences in the photosynthetic sea slug Elysia crispata.The Journal of experimental biology · 2026Article
- Article
- Use of medicinal plants and plant extracts as nutritional and immunological additives in aquaculture: A review study.Open veterinary journal · 2026Review
- Bacterial Single-Cell Proteins as Sustainable Aquafeeds: A Meta-Analysis of Growth, Physiological Homeostasis, and Antioxidant Capacity.Aquaculture nutrition · 2026Review
- The Performance of Protein Meal fromInsects · 2025Article
- Polyethylene nanoplastics intensify toxicity of potassium clavulanate in African catfish (Clarias gariepinus).Scientific reports · 2025Article
- Physiological Stress Responses Associated with Microplastic Ingestion in the Benthic FlatfishToxics · 2025Article
- Toxicological Responses of Juvenile Gilthead Seabream to Enniatin B and Fumonisin B1.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmaceutical residues are a result of human activities and are increasingly recognized as environmental contaminants that pose significant risks to aquatic ecosystems. There are many well-known pathways (agricultural runoff, veterinary use, human excretion, etc.) for the entry of these pharmaceuticals into the aquatic environment, and among them, the inability to remove these biologically active compounds from wastewater treatment plant (WWTP) effluents is becoming increasingly significant in the context of societal evolution. Once introduced, pharmaceuticals persist at low concentrations, exerting sub-lethal effects that disrupt the physiological processes of aquatic organisms. Among these effects, oxidative stress (OS) has gained attention as a key mechanism that is induced by pharmaceutical toxicity, serving as a sentinel indicator of homeostatic disturbance. Thus, studying OS biomarkers in fish is crucial for understanding the extent of pharmaceutical pollution, as these biomarkers provide early warning signals of environmental stress and help assess sub-lethal impacts on aquatic organisms. Their application, correlated with other eco-physiological investigations, can improve ecological risk assessments. In this context, this review explores the role of OS biomarkers by assessing the effects of pharmaceutical contaminants on fish. It highlights the utility and limitations of these biomarkers for environmental monitoring, while also identifying key research gaps-particularly regarding long-term ecological consequences.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.