Curcumin Nanocarriers in the Protection Against Iron- and Alcohol-Induced Oxidative Stress in a Cellular Model of Liver Disease.

Lucy Petagine, Mohammed G Zariwala, Satyanarayana Somavarapu, Stefanie Ho Yi Chan, Vinood B Patel

Abstract read

In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lucy PetagineCentre for Nutraceuticals, School of Life Sciences, University of Westminster, London W1W 6UW, UK.ORCID 0000-0003-2457-4001

Mohammed G ZariwalaCentre for Nutraceuticals, School of Life Sciences, University of Westminster, London W1W 6UW, UK.ORCID 0000-0001-9944-8451

Satyanarayana SomavarapuDepartment of Pharmaceutics, UCL School of Pharmacy, London WC1N 1AX, UK.ORCID 0000-0001-5361-4610

Stefanie Ho Yi ChanCentre for Nutraceuticals, School of Life Sciences, University of Westminster, London W1W 6UW, UK.ORCID 0000-0002-1912-3081

Vinood B PatelCentre for Nutraceuticals, School of Life Sciences, University of Westminster, London W1W 6UW, UK.ORCID 0000-0001-9334-2525

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During chronic alcohol misuse, hepatic iron overload occurs, leading to exacerbated oxidative stress and liver injury. The aim was to study formulations encapsulated with the antioxidant curcumin to assess their ability protect against oxidative stress in a model of alcohol-related liver disease (ALD) combined with iron. HepG2 (VL-17A) cells were treated with iron (50 µM) alone or with alcohol (200 to 350 mM) over 72 h and markers of oxidative damage, cell death, and mitochondrial function were assessed. Nanoformulations encapsulating curcumin were also studied. VL-17A cells treated with both ethanol and iron showed significant decreases in cell viability (64%,

Indexed as

alcoholantioxidantscurcuminironlivermitochondriaoxidative stressreactive oxygen species

Identifiers

PMID40427645

DOI10.3390/biology14050455

PMCPMC12109286

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.