Evidence map›Paper›PMID 40427641›Full record

ArticleBiomolecules2025

Neuronal Plasticity-Dependent Paradigm and Young Plasma Treatment Prevent Synaptic and Motor Deficit in a Rett Syndrome Mouse Model.

Sofía Espinoza, Camila Navia, Rodrigo F Torres, Nuria Llontop, Verónica Valladares, Cristina Silva, Ariel Vivero, Exequiel Novoa-Padilla, Jessica Soto-Covasich, Jessica Mella and 9 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sofía EspinozaCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago 7510157, Chile.ORCID 0000-0001-6363-5896
Camila NaviaCentro de Estudios Científicos (CECs), Valdivia 5110466, Chile.
Rodrigo F TorresCentro de Estudios Científicos (CECs), Valdivia 5110466, Chile.ORCID 0000-0002-4328-2920
Nuria LlontopCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago 7510157, Chile.ORCID 0000-0002-1490-0806
Verónica ValladaresCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago 7510157, Chile.
Cristina SilvaCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago 7510157, Chile.ORCID 0009-0000-9882-921X
Ariel ViveroCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago 7510157, Chile.
Exequiel Novoa-PadillaCentro de Estudios Científicos (CECs), Valdivia 5110466, Chile.
Jessica Soto-CovasichCentro de Estudios Científicos (CECs), Valdivia 5110466, Chile.
Jessica MellaNeuromuscular Studies Laboratory (NeSt Lab), Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia 5091000, Chile.
Ricardo KouroCentro de Estudios Científicos (CECs), Valdivia 5110466, Chile.
Sharin ValdiviaCentro de Estudios Científicos (CECs), Valdivia 5110466, Chile.
Marco Pérez-BustamanteCentro de Estudios Científicos (CECs), Valdivia 5110466, Chile.
Patricia Ojeda-ProvosteCentro de Estudios Científicos (CECs), Valdivia 5110466, Chile.ORCID 0009-0006-5493-7212
Nancy PinedaCentro de Estudios Científicos (CECs), Valdivia 5110466, Chile.
Sonja BuvinicFacultad de Odontología, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0002-2286-2918
Dasfne Lee-LiuEscuela de Química y Farmacia, Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago 7510157, Chile.ORCID 0000-0003-1449-4104
Juan Pablo HenríquezNeuromuscular Studies Laboratory (NeSt Lab), Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia 5091000, Chile.
Bredford KerrCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Providencia, Santiago 7510157, Chile.ORCID 0000-0001-8714-8726

Funding

Anillo ACT210039Fondecyt 3180518Fondecyt Postdoctorado 3210493Fondecyt Regular 11230898Fondecyt Regular 1181574Fondecyt Regular 1221213
6 · The paper itself

Abstract

Classical Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the

Indexed as

Neuronal PlasticityRett SyndromeSynapsesAnimalsDisease Models, AnimalMaleMethyl-CpG-Binding Protein 2MiceMice, KnockoutNeuromuscular JunctionMecp2 protein, mouseMethyl-CpG-Binding Protein 2environmental enrichmentMecp2plasma treatmentRett syndrome

Identifiers

PMID40427641
PMCPMC12109941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.