Evidence map›Paper›PMID 40427637›Full record

ArticleBiomolecules2025

Modulation of Kv Channel Gating by Light-Controlled Membrane Thickness.

Rohit Yadav, Juergen Pfeffermann, Nikolaus Goessweiner-Mohr, Toma Glasnov, Sergey A Akimov, Peter Pohl

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Fluctuating hydrogen-bond network of the Hv1 ion channel.Computational and structural biotechnology journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rohit YadavInstitute of Biophysics, Johannes Kepler University Linz, 4040 Linz, Austria.ORCID 0009-0000-9634-3291
Juergen PfeffermannInstitute of Biophysics, Johannes Kepler University Linz, 4040 Linz, Austria.ORCID 0000-0002-6184-6101
Nikolaus Goessweiner-MohrInstitute of Biophysics, Johannes Kepler University Linz, 4040 Linz, Austria.ORCID 0000-0002-6572-5606
Toma GlasnovInstitute of Chemistry, Karl-Franzens-University, 8010 Graz, Austria.
Sergey A AkimovFrumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow 119071, Russia.ORCID 0000-0002-7916-6032
Peter PohlInstitute of Biophysics, Johannes Kepler University Linz, 4040 Linz, Austria.ORCID 0000-0002-1792-2314

Funding

FWF Austrian Science Fund TAI181
6 · The paper itself

Abstract

Voltage-gated potassium (Kv) channels are e ssential for shaping action potentials and rely on anionic lipids for proper gating, yet the mechanistic basis of lipid-channel interactions remains unclear. Cryo-electron microscopy studies suggest that, in the down state, arginine residues of the voltage sensor draw lipid phosphates upward, leading to a local membrane thinning of ~5 Å-an effect absent in the open state. To test whether membrane thickness directly affects voltage sensor function, we reconstituted Kv channels from

Indexed as

AeropyrumCell MembraneIon Channel GatingLightLipid BilayersPotassium Channels, Voltage-GatedLipid BilayersPotassium Channels, Voltage-GatedelectrophysiologyKv channelphotoswitchable lipidsvoltage sensor

Identifiers

PMID40427637
PMCPMC12109740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.