Evidence map›Paper›PMID 40427601›Full record

ArticleBiomolecules2025

Examining the Effects of the RUNX1 p.Leu43Ser Variant on FPD/AML Phenotypes Using a CRISPR/Cas9-Generated Knock-In Murine Model.

Ana Marin-Quilez, Ignacio García-Tuñón, Rocío Benito, José Luis Ordoñez, Lorena Díaz-Ajenjo, Ana Lama-Villanueva, Carmen Guerrero, Jesús Pérez-Losada, José Ramón González-Porras, Jesús María Hernández-Rivas and 2 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ana Marin-QuilezCancer Research Center-CSIC, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-2005-1919
Ignacio García-TuñónCancer Research Center-CSIC, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-4758-2151
Rocío BenitoCancer Research Center-CSIC, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-9781-4198
José Luis OrdoñezCancer Research Center-CSIC, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-3791-4215
Lorena Díaz-AjenjoCancer Research Center-CSIC, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-0716-385X
Ana Lama-VillanuevaCancer Research Center-CSIC, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.ORCID 0009-0007-0290-6825
Carmen GuerreroCancer Research Center-CSIC, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-8747-6831
Jesús Pérez-LosadaCancer Research Center-CSIC, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-2400-624X
José Ramón González-PorrasDepartment of Hematology, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigación Biomédica de Salamanca (IBSAL), Universidad de Salamanca (USAL), 37007 Salamanca, Spain.ORCID 0000-0003-3266-7996
Jesús María Hernández-RivasCancer Research Center-CSIC, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-9661-9371
Mónica Del ReyCancer Research Center-CSIC, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-1048-8148
José María BastidaDepartment of Hematology, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigación Biomédica de Salamanca (IBSAL), Universidad de Salamanca (USAL), 37007 Salamanca, Spain.ORCID 0000-0002-8007-3909

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Germline heterozygous variants in

Indexed as

Blood Platelet DisordersCore Binding Factor Alpha 2 SubunitCRISPR-Cas SystemsLeukemia, Myeloid, AcuteAnimalsDisease Models, AnimalGene Knock-In TechniquesHomozygoteMaleMicePhenotypeCore Binding Factor Alpha 2 SubunitRunx1 protein, mouseFPD/AMLmurine modelmyeloid neoplasmRNA-seqRUNX1

Identifiers

PMID40427601
PMCPMC12109519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.