Evidence map›Paper›PMID 40427591›Full record

ArticleBiomolecules2025

LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo Implantation in Mice.

Jumpei Terakawa, Sakura Nakamura, Mana Ohtomo, Saki Uehara, Yui Kawata, Shunsuke Takarabe, Hibiki Sugita, Takafumi Namiki, Atsuko Kageyama, Michiko Noguchi and 3 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jumpei TerakawaGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.ORCID 0000-0002-7643-7976
Sakura NakamuraGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.
Mana OhtomoGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.
Saki UeharaGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.
Yui KawataLaboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan.ORCID 0009-0000-8870-910X
Shunsuke TakarabeGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.
Hibiki SugitaGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.
Takafumi NamikiGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.ORCID 0009-0004-6691-2448
Atsuko KageyamaLaboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan.
Michiko NoguchiGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.ORCID 0009-0005-3230-4580
Hironobu MurakamiGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.ORCID 0000-0002-7560-4445
Naomi KashiwazakiGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.
Junya ItoGraduate School of Veterinary Science, Azabu University, Kanagawa 252-5201, Japan.ORCID 0000-0001-9398-7358

Funding

Japan Society for the Promotion of Science JP21K09512, JP24K01950, JP21K05977, JP20H05373, JP21H02384
6 · The paper itself

Abstract

In eutherian mammals, embryo implantation is a critical process for a successful pregnancy. In mice, the activation of the leukemia inhibitory factor (LIF) receptor-STAT3 signaling axis induces embryo adhesion and decidualization. The LIF receptor is believed to function as a heterodimer composed of LIFR (encoded by

Indexed as

Embryo ImplantationErb-b2 Receptor Tyrosine KinasesLeukemia Inhibitory Factor Receptor alpha SubunitSignal TransductionAnimalsCytokine Receptor gp130EndometriumFemaleMiceMice, KnockoutPregnancyUterusCytokine Receptor gp130Erbb2 protein, mouseErb-b2 Receptor Tyrosine KinasesIl6st protein, mouseLeukemia Inhibitory Factor Receptor alpha SubunitLifr protein, mouseembryo implantationERBB2Gp130LIFLIFR

Identifiers

PMID40427591
PMCPMC12109566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.