Evidence map›Paper›PMID 40427586›Full record

ReviewBiomolecules2025

Celebrating Ulrik Ringborg: Multi-Omics-Based Patient Stratification for Precision Cancer Treatment.

Maria-Veronica Teleanu, Annika Schneider, Claudia R Ball, Mathias Felix Leber, Christoph Stange, Eva Krieghoff-Henning, Katja Beck, Christoph E Heilig, Simon Kreutzfeldt, Bernhard Kuster and 2 more

Abstract readReview
In one paragraph

Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Integrating multi-omics data for next-generation cancer research and precision medicine.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  3. Review
  4. Targeted therapy in patients with genetic tumor syndromes.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria-Veronica TeleanuDivision of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-2176-6158
Annika SchneiderSchool of Life Sciences, Technical University Munich, 85354 Freising, Germany.ORCID 0000-0002-7684-7801
Claudia R BallDepartment of Translational Medical Oncology, National Center for Tumor Diseases (NCT)/University Cancer Center Dresden, a Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology (TUD), and Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.ORCID 0000-0002-1749-3791
Mathias Felix LeberNational Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0002-8773-1169
Christoph StangeSchool of Life Sciences, Technical University Munich, 85354 Freising, Germany.
Eva Krieghoff-HenningDivision of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Katja BeckDivision of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Christoph E HeiligDivision of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Simon KreutzfeldtDivision of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Bernhard KusterSchool of Life Sciences, Technical University Munich, 85354 Freising, Germany.ORCID 0000-0002-9094-1677
Daniel B LipkaDivision of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0001-5081-7869
Stefan FröhlingDivision of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0001-7907-4595

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision oncology is becoming a mainstay in the standard of care for cancer patients. Recent technological advancements have significantly lowered the cost of various tumor profiling approaches, broadening the reach of molecular diagnostics and improving patient access to precision oncology. In parallel, drug development and discovery pipelines continue to evolve, driving targeted therapeutic options forward. Yet, not all patients harboring actionable molecular alterations respond to these interventions, and existing therapies do not cover the entire spectrum of potential molecular targets. In this review, we examine the current suite of omics technologies employed in clinical settings and underscore their roles in deepening our understanding of tumor biology and optimizing patient stratification for targeted treatments. We also highlight relevant precision oncology trials and share our own experiences using multi-omics data within a molecular tumor board framework. Finally, we discuss areas for future exploration aimed at propelling precision oncology to new heights.

Indexed as

Computational BiologyNeoplasmsPrecision MedicineAntineoplastic AgentsDrug DiscoveryHumansAntineoplastic Agentsmolecular profilingpatient stratificationprecision oncology

Identifiers

PMID40427586
PMCPMC12108785

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.