Evidence map›Paper›PMID 40427580›Full record

ArticleBiomolecules2025

Martina Mietto, Silvia Montanari, Maria Sofia Falzarano, Elisa Manzati, Paola Rimessi, Marina Fabris, Rita Selvatici, Francesca Gualandi, Marcella Neri, Fernanda Fortunato and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Martina MiettoMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Silvia MontanariMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0009-0007-3189-9353
Maria Sofia FalzaranoMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-5619-628X
Elisa ManzatiMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Paola RimessiMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Marina FabrisMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Rita SelvaticiMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-3099-0100
Francesca GualandiMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-9551-057X
Marcella NeriMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-6133-9831
Fernanda FortunatoMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0232-196X
Miryam Rosa Stella FotiMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0009-0002-0335-5862
Stefania BigoniMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Marco GessiPathology Institute, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Marcella VaccaInstitute of Genetics and Biophysics "A. Buzzati-Traverso", CNR, 80131 Naples, Italy.ORCID 0000-0002-5495-9183
Silvia TorelliThe Dubowitz Neuromuscular Centre, UCL Great Ormond Street Institute of Child Health, London WC1E 6BT, UK.ORCID 0000-0002-8840-6835
Joussef HayekChild Neuropsychiatry Unit, University Hospital, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy.
Alessandra FerliniMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-8385-9870

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rett syndrome (RTT) is a rare X-linked dominant neurodevelopmental disorder caused by pathogenic variants in the methyl-CpG-binding protein 2 (

Indexed as

BrainMethyl-CpG-Binding Protein 2Rett SyndromeRNA, MessengerAllelesFemaleHumansMaleMutationTranscription, GeneticX Chromosome InactivationMECP2 protein, humanMethyl-CpG-Binding Protein 2RNA, Messengerhuman brainMECP2 transcription profilingRett syndrome (RTT)X-chromosome inactivation (XCI)

Identifiers

PMID40427580
PMCPMC12108707

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.