Evidence map›Paper›PMID 40427565›Full record

ArticleBiomolecules2025

Sex Differences in Brain Transcriptomes of Juvenile Cynomolgus Macaques.

Nadia Kabbej, Frederick J Ashby, Alberto Riva, Paul D Gamlin, Ronald J Mandel, Aishwarya Kunta, Courtney J Rouse, Coy D Heldermon

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In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Nadia KabbejDepartment of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Frederick J AshbyDepartment of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-6975-8990
Alberto RivaBioinformatics Core, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0001-9150-8333
Paul D GamlinDepartment of Ophthalmology & Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Ronald J MandelDepartment of Neuroscience, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-4070-725X
Aishwarya KuntaDepartment of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Courtney J RouseDepartment of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Coy D HeldermonDepartment of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-2148-2868

Funding

Optimizing AAV Vectors for Central Nervous System transductionR01NS102624 · NINDS · UNIVERSITY OF FLORIDA · PI HELDERMON, COY D · 2017 to 2021
$2.6M
NIH HHS 1R01NS102624-22A1NINDS NIH HHS R01 NS102624
6 · The paper itself

Abstract

backgroundBehavioral, social, and physical characteristics are posited to distinguish the sexes, yet research on transcription-level sexual differences in the brain is limited. Here, we investigated sexually divergent brain transcriptomics in pre-pubertal cynomolgus macaques, a commonly used surrogate species to humans.

methodsA transcriptomic profile using RNA sequencing was generated for the temporal lobe, ventral midbrain, and cerebellum of three female and three male cynomolgus macaques previously treated with an adeno-associated virus vector mix. Statistical analyses to determine differentially expressed protein-coding genes in all three lobes were conducted using DeSeq2 with a false-discovery-rate-corrected

resultsWe identified target genes in the temporal lobe, ventral midbrain, and cerebellum with functions in translation, immunity, behavior, and neurological disorders that exhibited statistically significant sexually divergent expression.

conclusionsWe provide potential mechanistic insights into the epidemiological differences observed between the sexes with regard to mental health and infectious diseases, such as COVID-19. Our results provide pre-pubertal information on sexual differences in non-human primate brain transcriptomics and may provide insight into health disparities between the biological sexes in humans.

Indexed as

BrainMacaca fascicularisSex CharacteristicsTranscriptomeAnimalsCerebellumCOVID-19FemaleGene Expression ProfilingMaleTemporal LobebehaviorCOVID-19cynomolgus macaquesimmunitypre-pubertalsexual dimorphismtranscriptomicstranslation

Identifiers

PMID40427565
PMCPMC12109503

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.