Evidence map›Paper›PMID 40427564›Full record

ReviewBiomolecules2025

The Critical Balance Between Quiescence and Reactivation of Neural Stem Cells.

Adam M Elkin, Sarah Robbins, Claudia S Barros, Torsten Bossing

Abstract readReview
In one paragraph

Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The Hox Gene,Molecular biology of the cell · 2025
    Article
  3. The Hox Gene,bioRxiv : the preprint server for biology · 2025
    Article
  4. Quiescence Multiverse.Biomolecules · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adam M ElkinPeninsula Medical School, Faculty of Health, University of Plymouth, Plymouth PL6 8BU, UK.ORCID 0000-0003-1719-561X
Sarah RobbinsPeninsula Medical School, Faculty of Health, University of Plymouth, Plymouth PL6 8BU, UK.
Claudia S BarrosPeninsula Medical School, Faculty of Health, University of Plymouth, Plymouth PL6 8BU, UK.ORCID 0000-0003-0361-0333
Torsten BossingPeninsula Medical School, Faculty of Health, University of Plymouth, Plymouth PL6 8BU, UK.ORCID 0000-0002-3277-9130

Funding

Peninsula Medical Foundation N.A.Peninsula Medical School N.A.
6 · The paper itself

Abstract

Neural stem cells (NSC) are multipotent, self-renewing cells that give rise to all neural cell types within the central nervous system. During adulthood, most NSCs exist in a quiescent state which can be reactivated in response to metabolic and signalling changes, allowing for long-term continuous neurogenesis and response to injury. Ensuring a critical balance between quiescence and reactivation is required to maintain the limited NSC reservoir and neural replenishment throughout lifetime. The precise mechanisms and signalling pathways behind this balance are at the focus of current research. In this review, we highlight and discuss recent studies using

Indexed as

Neural Stem CellsAnimalsDrosophilaHumansNeurogenesisSignal TransductionZebrafishdamage repairneural stem cellsquiescencereactivation

Identifiers

PMID40427564
PMCPMC12108614

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.