Evidence map›Paper›PMID 40427550›Full record

ArticleBiomolecules2025

Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies.

Chiara Giorgi, Francesca Lombardi, Francesca Rosaria Augello, Ylli Alicka, Massimiliano Quintiliani, Skender Topi, Annamaria Cimini, Vanessa Castelli, Michele d'Angelo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chiara GiorgiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0009-0000-4210-9141
Francesca LombardiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-0551-5076
Francesca Rosaria AugelloDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Ylli AlickaDepartment of Clinical Disciplines, University "Alexander Xhuvani" of Elbasan, 3001 Elbasan, Albania.ORCID 0000-0002-3386-8549
Massimiliano QuintilianiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Skender TopiDepartment of Clinical Disciplines, University "Alexander Xhuvani" of Elbasan, 3001 Elbasan, Albania.ORCID 0000-0002-6661-8116
Annamaria CiminiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-2737-7970
Vanessa CastelliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-7005-3218
Michele d'AngeloDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-3693-840X

Funding

MIUR DM61317
6 · The paper itself

Abstract

Breast and ovarian cancers are among the most prevalent cancers in women. Cancerous cells are characterized by their ability to continuously cycle and migrate, forming metastases. Some probiotic strains have shown anti-tumorigenic effects. This study tested the impact of probiotics on OVCAR-3 and MDA-MB-231 cell lines by analyzing proteins involved in cell cycle regulation (pP53, Cyclin D1, pERK1), cell survival (AKT), and cell migration (RhoA) using Western blotting and scratch wound tests. Results indicated a reduction in these proteins and decreased cell migration velocity post-treatment. These findings suggest that certain probiotic combinations can arrest the cell cycle, promote cell death, and reduce cell migration, potentially serving as promising candidates alongside standard therapies.

Indexed as

Antineoplastic AgentsBreast NeoplasmsOvarian NeoplasmsProbioticsCell CycleCell Line, TumorCell MovementCell ProliferationCell SurvivalFemaleHumansAntineoplastic Agentsbreast cancercancercell cyclemigrationovarian cancertriple negative

Identifiers

PMID40427550
PMCPMC12108976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.