Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration.

Nathalie Daude, Ivana Machado, Luis Arce, Jing Yang, David Westaway

Abstract read

In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nathalie DaudeCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 8M8, Canada.ORCID 0000-0001-5217-7826

Ivana MachadoCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 8M8, Canada.

Luis ArceCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 8M8, Canada.

Jing YangCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 8M8, Canada.

David WestawayCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB T6G 8M8, Canada.ORCID 0000-0003-1928-4616

Funding

Alberta Prion Research Institute APRIIEP201600033Campus Alberta Neuroscience N/ACanada Foundation for Innovation NIF 21633Canada Foundation for Innovation NIF 39588CIHR 16308CIHR 173286Hope for Tomorrow N/ANanostring AD panel N/ASynAD ADRD N/A

6 · The paper itself

Abstract

Slow-onset neurodegenerative disease in a low-expresser 2N4R P301L transgenic (Tg) mouse model is marked by neuroinflammation and by differing patterns of CNS deposition and accumulation of tau conformers, with such heterogeneities present even within inbred backgrounds. Gut microbial genotypes were notably divergent within C57BL6/Tac or 129SvEv/Tac congenic (Cg) sublines of TgTau

Indexed as

Frontotemporal Lobar DegenerationGastrointestinal MicrobiomeAnimalsDisease Models, AnimalGenetic BackgroundHumansMaleMiceMice, Inbred C57BLMice, Transgenictau Proteinstau Proteinsfrontotemporal dementiainbred strainmicrobiomeneurodegenerationneuroinflammationprotein misfoldingtauopathytransgenic mouse

Identifiers

PMID40427529

DOI10.3390/biom15050636

PMCPMC12109532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.