Evidence map›Paper›PMID 40427528›Full record

ArticleBiomolecules2025

Structural and Functional Analysis of the Human IQSEC2 S1474Qfs*133 Mutation.

Yonat Israel, Aaron Lowenkamp, Michael Shokhen, Shai Netser, Shlomo Wagner, Joseph Zarowin, Shaun Orth, Veronika Borisov, Orit Lache, Nina S Levy and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yonat IsraelFaculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel.
Aaron LowenkampFaculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel.
Michael ShokhenDepartment of Chemistry, Bar Ilan University, Ramat-Gan 5290002, Israel.
Shai NetserSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 3103301, Israel.ORCID 0000-0003-4176-1124
Shlomo WagnerSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 3103301, Israel.ORCID 0000-0002-7618-0752
Joseph ZarowinFaculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel.
Shaun OrthFaculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel.
Veronika BorisovFaculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel.
Orit LacheFaculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel.
Nina S LevyFaculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel.
Andrew P LevyFaculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel.

Funding

Israel Science Foundation 591/23
6 · The paper itself

Abstract

IQSEC2 is a guanine nucleotide exchange factor that modulates synaptic transmission, the excitatory/inhibitor balance and memory consolidation. Pathogenic mutations in the

Indexed as

Guanine Nucleotide Exchange FactorsAnimalsFrameshift MutationHumansMaleMiceMice, TransgenicModels, MolecularMutationGuanine Nucleotide Exchange FactorsIQSEC2 protein, humanconditional mutationIQSEC2molecular modelingneurodevelopmental delay

Identifiers

PMID40427528
PMCPMC12109076

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.