Evidence map›Paper›PMID 40427462›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway.

Runtian Li, Lintao Li, Haiyang Wu, Hui Gan, Zhuona Wu, Ruolan Gu, Xiaoxia Zhu, Shuchen Liu, Zhiyun Meng, Guifang Dou

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. International journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Antioxidants (Basel, Switzerland) · 2026
    Article
  8. The Role ofDermatology research and practice · 2026
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Runtian LiBeijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
Lintao LiSchool of Public Health, University of South China, Hengyang 421001, China.
Haiyang WuBeijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
Hui GanBeijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
Zhuona WuBeijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
Ruolan GuBeijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
Xiaoxia ZhuBeijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
Shuchen LiuBeijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
Zhiyun MengBeijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
Guifang DouBeijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.ORCID 0000-0001-5004-2194

Funding

Bejing Science and Tchenology Program No.1916315ZD00900104
6 · The paper itself

Abstract

Radiation-induced intestinal injury (RIII) is a significant concern for cancer patients receiving radiation therapy, as it can lead to complications such as radiation enteropathy. Presently, there are limited options for preventing or treating RIII. Tea polyphenols (TP), found in tea, provide various health benefits, but their antiradiation mechanisms are not fully understood. C57BL/6 mice pre-treated with TP for five days showed a significant improvement in survival rates after being exposed to 10 Gy of

Indexed as

ferroptosisgut microbiotaHSP90metabolitesradiation-induced intestinal injurytea polyphenol

Identifiers

PMID40427462
PMCPMC12108355

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.