ArticleAntioxidants (Basel, Switzerland)2025
Gingival Inflammation Modulates NLRP3 Inflammasome Signalling in Peripheral Blood Mononuclear Cells of PCOS Patients: A Case-Control Study.
Cecilia Fabiana Márquez-Arrico, María Pelechá-Salvador, Meylin Fernández-Reyes, Francisco Javier Silvestre, Laura Perea-Galera, Jonathan Hermenejildo, Zaida Abad-Jiménez, Javier Silvestre-Rangil, Carlos Morillas, Víctor M Víctor and 2 more
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In one paragraphArticle in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
12 authors.
Cecilia Fabiana Márquez-ArricoDepartment of Stomatology, University of Valencia, 46010 Valencia, Spain.
María Pelechá-SalvadorDepartment of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research, 46017 Valencia, Spain.
Meylin Fernández-ReyesDepartment of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research, 46017 Valencia, Spain.
Laura Perea-GaleraDepartment of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research, 46017 Valencia, Spain.ORCID 0009-0001-3719-3614 Jonathan HermenejildoDepartment of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research, 46017 Valencia, Spain.ORCID 0000-0001-8954-6621 Zaida Abad-JiménezDepartment of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research, 46017 Valencia, Spain.
Javier Silvestre-RangilDepartment of Stomatology, University of Valencia, 46010 Valencia, Spain.
Carlos MorillasDepartment of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research, 46017 Valencia, Spain.ORCID 0000-0002-3745-4423 Víctor M VíctorDepartment of Physiology, Biomedical Research Institute Valencia (INCLIVA), University of Valencia, 46010 Valencia, Spain.
Sandra López-DomènechDepartment of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research, 46017 Valencia, Spain.ORCID 0000-0003-2067-9308 Milagros RochaDepartment of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research, 46017 Valencia, Spain.ORCID 0000-0003-2923-6546 Funding
European Commission 101136516Generalitat Valenciana CIGRIS/2021/112Generalitat Valenciana CIPROM/2022/32Generalitat Valenciana INVEST/2023/163Instituto de Salud Carlos III CD23/0006Instituto de Salud Carlos III FI23/00141Instituto de Salud Carlos III PI22/00424Instituto de Salud Carlos III PI22/1009Ministerio de Ciencia, Innovación y Universidades FPU18/00854National Network of Biomedical Research on Hepatic and Digestive Diseases (CIBEREHD) CB06/04/0071
6 · The paper itselfAbstract
Polycystic ovary syndrome (PCOS) is a complex condition associated with chronic inflammation and oxidative stress and is often linked to periodontal diseases. This study aimed to determine whether gingivitis modulates the NLRP3 inflammasome in peripheral blood mononuclear cells (PBMCs) from women with PCOS. Following a case-control design, 104 women were divided into three groups: controls (n = 36), PCOS without gingivitis (PCOS, n = 44) and PCOS with gingivitis (PCOS+, n = 24). Periodontal parameters, proinflammatory regulators (NFκB p65, JNK), NLRP3 components (NLRP3, ASC, procaspase-1, caspase-1) and oxidative stress markers (superoxide,
Indexed as
gingivitisinflammasomeNLRP3 proteinPBMCsperiodontal diseasepolycystic ovary syndrome
Identifiers
PMID40427389
PMCPMC12108338
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