ArticleAnimals : an open access journal from MDPI2025
Serum Concentrations of Insulin-like Growth Factor-1 (IGF-1), 26S Proteasome (26S PSM), and 3-Methylhistidine (3-MH) in Cats with Hypertrophic Cardiomyopathy.
Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiovascular biomarkers in feline hypertrophic cardiomyopathy phenotype: evidence from the last decade.Veterinary research communications · 2026Pooled it
- Linking clinical and imaging diagnostic assessments of the feline hypertrophic cardiomyopathy phenotype.Frontiers in veterinary science · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiomyopathies not only affect the cardiovascular system but can also have systemic implications. Despite their significance, only a few laboratory parameters are currently used to describe the metabolic effects of cardiomyopathies. This study aimed to explore a potential link between hypertrophic cardiomyopathy (HCM) and serum IGF-1, 26S PSM, and 3-MH concentrations in cats. MATERIALS AND
methodsSerum IGF-1, 26S PSM, and 3-MH concentrations were measured using ELISA in cats diagnosed with HCM (
resultsCats with HCM exhibited elevated median serum IGF-1 and 3-MH concentrations compared to the control group, suggesting metabolic alterations. While 26S PSM levels did not differ significantly, 3-MH concentrations showed a non-significant tendency to higher serum concentrations in cats categorized as C-D than in those classified as B1-B2.
conclusionsThese findings suggest a potential interplay between HCM and protein metabolism in cats, highlighting the relevance of metabolic biomarkers in understanding disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.