Evidence map›Paper›PMID 40427224›Full record

ArticleCancers2025

Radiological, Pathological, and Surgical Outcomes with Neoadjuvant Cemiplimab for Stage II-IV Cutaneous Squamous Cell Carcinoma in the Deep Sequencing in Cutaneous Squamous Cell Carcinomas (DISCERN) Trial.

Annette M Lim, Benjamin Baker, Peter Lion, Christopher M Angel, Jennifer Simmons, Bryce Jackson, Matthew Magarey, Angela Webb, Kevin Nguyen, Jo Hudson and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Annette M LimDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.ORCID 0000-0002-0777-2279
Benjamin BakerDepartment of Plastic Surgery, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK.ORCID 0000-0002-6741-5169
Peter LionDepartment of Head & Neck Surgery, University College London Hospitals NHS Foundation Trust, London NW1 2PG, UK.
Christopher M AngelDepartment of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Jennifer SimmonsParkville Cancer Clinical Trials Unit, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Bryce JacksonComplex Skin Unit, Department of Plastic Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.ORCID 0000-0002-4870-773X
Matthew MagareySir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia.
Angela WebbComplex Skin Unit, Department of Plastic Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.ORCID 0000-0002-0659-8029
Kevin NguyenDepartment of Head and Neck Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Jo HudsonDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Kwang Yang ChinSir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia.
Anthony CardinSir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia.
Rajeev RaviDepartment of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Edwin MorrisonComplex Skin Unit, Department of Plastic Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Tam QuinnComplex Skin Unit, Department of Plastic Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Ian HuntBiomathematics and Statistics Scotland, The James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
Danny RischinDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.

Funding

National Health and Medical Research Council APP1175929 received by DR contributed to the translational work and provides JH salary supportPeter MacCallum Cancer Centre SponsorshipRegeneron (United States) Institutional support for the DISCERN trial.
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cemiplimabCSCCcutaneous squamous cell carcinomaimmunotherapyiPERCISTneoadjuvantpathologyplasticradiologyskin cancersurgery

Identifiers

PMID40427224
PMCPMC12110075

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.