Evidence map›Paper›PMID 40427165›Full record

ReviewCancers2025

New Insights into Upper Tract Urothelial Carcinoma: Lessons Learned from the ROBUUST Collaborative Study.

Arianna Biasatti, Gabriele Bignante, Francesco Ditonno, Alessandro Veccia, Riccardo Bertolo, Alessandro Antonelli, Randall Lee, Daniel D Eun, Vitaly Margulis, Firas Abdollah and 27 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Arianna BiasattiDepartment of Urology, Rush University Medical Center, Chicago, IL 60612, USA.
Gabriele BignanteDepartment of Urology, Rush University Medical Center, Chicago, IL 60612, USA.ORCID 0009-0008-4269-6663
Francesco DitonnoDepartment of Urology, Rush University Medical Center, Chicago, IL 60612, USA.ORCID 0009-0005-0126-4731
Alessandro VecciaDepartment of Urology, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, 37126 Verona, Italy.ORCID 0000-0001-5947-3206
Riccardo BertoloDepartment of Urology, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, 37126 Verona, Italy.ORCID 0000-0003-0260-4601
Alessandro AntonelliDepartment of Urology, Azienda Ospedaliera Universitaria Integrata of Verona, University of Verona, 37126 Verona, Italy.
Randall LeeFox Chase-Temple Urologic Institute, Philadelphia, PA 19111, USA.
Daniel D EunFox Chase-Temple Urologic Institute, Philadelphia, PA 19111, USA.ORCID 0000-0001-7630-2740
Vitaly MargulisDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Firas AbdollahVattikuti Urology Institute, Henry Ford Hospital, Detroit, MI 48202, USA.
Takashi YoshidaDepartment of Urology and Andrology, Kansai Medical University, Hirakata 573-1191, Osaka, Japan.
Ithaar H DerweeshDepartment of Urology, UC San Diego School of Medicine, La Jolla, CA 92093, USA.
Margaret F MeagherDepartment of Urology, UC San Diego School of Medicine, La Jolla, CA 92093, USA.
Giuseppe SimoneDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, 00144 Rome, Italy.
Gabriele TudertiDepartment of Urology, IRCCS "Regina Elena" National Cancer Institute, 00144 Rome, Italy.
Eugenio BolognaDepartment of Urology, Rush University Medical Center, Chicago, IL 60612, USA.ORCID 0000-0002-1140-0590
Reza MehrazinDepartment of Urology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Soroush Rais-BahramiDepartment of Urology, School of Medicine, University of Alabama at Birmingham Heersink, Birmingham, AL 35294, USA.ORCID 0000-0001-9466-9925
Chandru P SundaramDepartment of Urology, Indiana University, Indianapolis, IN 47405, USA.
Courtney YongDepartment of Urology, Indiana University, Indianapolis, IN 47405, USA.
Andrea MinerviniUnit of Oncologic Minimally-Invasive Urology and Andrology, Department of Experimental and Clinical Medicine, Careggi University Hospital, University of Florence, 50134 Florence, Italy.
Andrea MariUnit of Oncologic Minimally-Invasive Urology and Andrology, Department of Experimental and Clinical Medicine, Careggi University Hospital, University of Florence, 50134 Florence, Italy.ORCID 0000-0001-9070-5706
Luca LambertiniUnit of Oncologic Minimally-Invasive Urology and Andrology, Department of Experimental and Clinical Medicine, Careggi University Hospital, University of Florence, 50134 Florence, Italy.
Matteo FerroDepartment of Health Science, ASST Santi Paolo and Carlo, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-9250-7858
Nirmish SinglaBrady Urological Institute, School of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Savio D PandolfoDepartment of Urology, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0001-9621-3059
Daniele AmparoreDivision of Urology, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, 10043 Orbassano, Italy.
Enrico CheccucciDepartment of Surgery, Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia, Istituto di Ricovero e Cura a Carattere Scientifico di Candiolo (IRCCS), Candiolo, 10060 Turin, Italy.ORCID 0000-0001-7901-5608
Mark L GonzalgoDesai Sethi Urology Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
James R PorterSwedish Medical Center, Seattle, WA 98122, USA.
Alireza GhoreifiDepartment of Urology, Duke University Medical Centre, Durham, NC 27708, USA.ORCID 0000-0002-7368-7240
Roberto ContieriIstituto Nazionale Tumori di Napoli, IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0001-7011-0537
Sisto PerdonàIstituto Nazionale Tumori di Napoli, IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Francesco PorpigliaDivision of Urology, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, 10043 Orbassano, Italy.ORCID 0000-0001-8567-6795
Hooman DjaladatInstitute of Urology, Kenneth Norris Jr. Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.
Saum GhodoussipourDivision of Urology, Section of Urologic Oncology, Rutgers Cancer Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.ORCID 0000-0001-8901-0210
Riccardo AutorinoDepartment of Urology, Rush University Medical Center, Chicago, IL 60612, USA.ORCID 0000-0001-7045-7725

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upper tract urothelial carcinoma (UTUC) is a rare malignancy, representing only 5-10% of urothelial carcinoma. The mainstay of treatment for high-risk patients is radical nephroureterectomy. Given the aggressive behavior of this disease, additional treatments could be required perioperatively in terms of chemotherapy (CHT), either in a neoadjuvant or adjuvant setting. On the other hand, low-risk and selected cases can be managed with kidney-sparing surgery (KSS). The ROBotic surgery for Upper tract Urothelial cancer STudy (ROBUUST) is an ongoing international, multicenter registry of patients undergoing surgery for UTUC. After conducting a literature search in February 2025 using the MEDLINE (via PubMed) and Embase databases, we identified 14 studies based on the ROBUUST data analyses. There are several key topics concerning UTUC that remain under debate and were therefore addressed in these studies, focusing on preoperative evaluation and planning, surgical techniques and intraoperative procedures, additional perioperative treatments, and outcomes. The ROBUUST registry has served as a valuable source for a growing body of investigations focusing on various aspects of UTUC treatment planning, decision-making, and outcomes, providing innovative tools and enabling large-scale, novel analyses.

Indexed as

ROBUUST 2.0ROBUUST registryUpper Tract Urothelial CarcinomaUrologic OncologyUTUC

Identifiers

PMID40427165
PMCPMC12110049

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.