Evidence map›Paper›PMID 40427128›Full record

ArticleCancers2025

Effectiveness of Systemic Corticosteroids in Managing Cancer-Related Neuropathic Pain: A Multicenter Prospective Observational Study.

Keita Tagami, Takaomi Kessoku, Hideaki Hasuo, Hiroto Ishiki, Takashi Yamaguchi, Masanori Mori, Yusuke Hiratsuka, Kazuhiro Kosugi, Yuka Okuda, Takeya Yamaguchi and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Keita TagamiDepartment of Home-Based Palliative Care, Yushoukai Home Medical Clinic Nerima, 1-22-11, Hazawa, Nerima-ku, Tokyo 176-0003, Japan.ORCID 0000-0001-8081-5979
Takaomi KessokuDepartment of Palliative Medicine and Gastroenterology, International University of Health and Welfare Narita Hospital, 852 Hatagateda, Narita 286-8250, Chiba, Japan.
Hideaki HasuoDepartment of Psychosomatic Medicine, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Osaka, Japan.ORCID 0000-0001-8094-9029
Hiroto IshikiDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuoku, Tokyo 104-0045, Japan.ORCID 0000-0002-0800-2161
Takashi YamaguchiDepartment of Palliative Care, Konan Medical Center, 1-5-16 Kamokogahara, Higashinada-ku, Kobe 658-0064, Hyogo, Japan.
Masanori MoriDivision of Palliative and Supportive Care, Seirei Mikatahara General Hospital, 3453 Mikatahara-cho, Chuo-ku, Hamamatsu 433-8558, Shizuoka, Japan.ORCID 0000-0002-5489-9395
Yusuke HiratsukaDepartment of Palliative Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan.ORCID 0000-0003-2334-3893
Kazuhiro KosugiDepartment of Palliative Medicine, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa 277-8577, Chiba, Japan.
Yuka OkudaDepartment of Anesthesiology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama-shi 641-8509, Wakayama, Japan.ORCID 0000-0001-7883-3940
Takeya YamaguchiDepartment of Palliative Care, JCHO Kyushu Hospital, 1-8-1 Kishinoura, Yahatanishi-ku, Kitakyushu 806-8501, Fukuoka, Japan.
Shingo MiyamotoDepartment of Medical Oncology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan.
Kiyofumi OyaPeace Home Care Clinic Kyoto, 11-43 Kamate-cho, Yamashina-ku, Kyoto 607-8031, Kyoto, Japan.
Kaoru NishijimaDepartment of Palliative Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan.
Yoshika KoinumaDepartment of Respiratory Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan.
Naoto MorikawaDepartment of Medical Oncology, Tohoku Rosai Hospital, 4-3 Dainohara, Aoba-ku, Sendai 981-8563, Miyagi, Japan.ORCID 0000-0002-4728-0965
Shunsuke OyamadaDepartment of Biostatistics, JORTC Data Center, 2-54-6-302, Nishinippori, Arakawa-ku, Tokyo 116-0013, Japan.
Keisuke AriyoshiDepartment of Data Management, JORTC Data Center, 2-54-6-302, Nishinippori, Arakawa-ku, Tokyo 116-0013, Japan.ORCID 0009-0002-8896-2572
Masaki HiguchiDepartment of Palliative Care, Eiju General Hospital, 2-23-16, Higashi-Ueno, Taito-ku, Tokyo 110-8645, Japan.
Hironori MawatariDepartment of Palliative and Supportive Care, Yokohama Minami Kyosai Hospital, 1-11-10, Mutsuurahigashi, Kanazawa-ku, Yokohama 236-0037, Kanagawa, Japan.
Kosuke TanakaDepartment of Palliative Medicine and Gastroenterology, International University of Health and Welfare Narita Hospital, 852 Hatagateda, Narita 286-8250, Chiba, Japan.
Mariko ShimazuDepartment of Psychosomatic Medicine, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Osaka, Japan.ORCID 0009-0005-3021-1401
Daisuke KiuchiDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuoku, Tokyo 104-0045, Japan.
Mamiko SatoDepartment of Palliative Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan.
Michihiro IwakiDepartment of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 1-4-1 Okina-cho, Naka-ku, Yokohama 231-0028, Kanagawa, Japan.
Rintaro KoikeDepartment of Palliative Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan.ORCID 0009-0003-9611-4634
Kazuki SatoNursing for Advanced Practice, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya 461-8673, Aichi, Japan.
Akira InoueDepartment of Palliative Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan.

Funding

MEXT/JSPS KAKENHI 21K18288Ministry of Education, Culture, Sports, Science and Technology 19K16939
6 · The paper itself

Abstract

backgroundCancer-related neuropathic pain (CR-NP) is challenging to manage, and the effectiveness of corticosteroids remains underexplored.

objectivesThis study investigated the analgesic and functional benefits of corticosteroids in CR-NP.

methodsThis multicenter, prospective observational study enrolled patients with CR-NP who initiated or escalated corticosteroid therapy. Pain intensity and daily activities were assessed at baseline (T0), 72 (T1), and 168 h (T2). A paired-sample

resultsIn total, 107 patients were consecutively enrolled. The mean worst pain intensity decreased from 8.2 ± 1.9 at T0 to 5.2 ± 2.9 at T1 and further to 4.4 ± 3.0 at T2. No significant correlation was found between changes in opioid daily dose and pain intensity. However, daily activities improved significantly in correlation with pain reduction (r = -0.36,

conclusionsCorticosteroids provided rapid and considerable analgesic and functional benefits for patients with CR-NP in this observational setting; further validation through comparative controlled studies is required.

Indexed as

braincancercancer paincorticosteroidsinflammationneuropathic painneuropathypalliative careprimary sensory neuronsspinal cord

Identifiers

PMID40427128
PMCPMC12109982

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.