Evidence map›Paper›PMID 40427091›Full record

ArticleBiomedicines2025

Last Resort? Rationale for Comprehensive Molecular Analysis in Treatment-Refractory R/M HNSCC: A Case Report of Remarkable Response to Sacituzumab Govitecan Following Molecular and Functional Characterization.

Henrike Barbara Zech, Philippe Schafhausen, Leonie Ramke, Janna-Lisa Velthaus, Simon Kreutzfeldt, Daniel Hübschmann, Kai Rothkamm, Carsten Bokemeyer, Anna Sophie Hoffmann, Stefan Fröhling and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Henrike Barbara ZechDepartment of Otorhinolaryngology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0002-3514-1976
Philippe Schafhausen2nd Department of Medicine (Oncology, Hematology, Bone Marrow Transplantation with Section Pneumology) and University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Leonie RamkeDepartment of Otorhinolaryngology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Janna-Lisa Velthaus2nd Department of Medicine (Oncology, Hematology, Bone Marrow Transplantation with Section Pneumology) and University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Simon KreutzfeldtDivision of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Daniel HübschmannDivision of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Kai RothkammDepartment of Radiotherapy & Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0001-7414-5729
Carsten Bokemeyer2nd Department of Medicine (Oncology, Hematology, Bone Marrow Transplantation with Section Pneumology) and University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Anna Sophie HoffmannDepartment of Otorhinolaryngology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Stefan FröhlingDivision of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0001-7907-4595
Hanno GlimmDepartment of Translational Medical Oncology, NCT, NCT/University Cancer Center Dresden, a Partnership Between German Cancer Research Center (DKFZ), Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology (TUD), and Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
Christian Stephan BetzDepartment of Otorhinolaryngology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0003-3188-1026
Malte KriegsDepartment of Radiotherapy & Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Maximilian Christopeit2nd Department of Medicine (Oncology, Hematology, Bone Marrow Transplantation with Section Pneumology) and University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

kinomeprecision medicinerecurrent HNSCCSacituzumab govitecanTrop-2tumor modelstumor tissue slices

Identifiers

PMID40427091
PMCPMC12108840

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.