Evidence map›Paper›PMID 40426750›Full record

ArticleChildren (Basel, Switzerland)2025

Bronchiolitis: A Real-Life Report of Increasing Compliance to Treatment Guidelines.

Melodie O Aricò, Francesco Accomando, Daniela Trotta, Anthea Mariani, Claudia Rossini, Claudio Cafagno, Letizia Lorusso, Enrico Valletta, Desiree Caselli, Maurizio Aricò

Abstract read
In one paragraph

Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Survey of Practice Variations in Management of Acute Viral Bronchiolitis in India (PRERNI-PAVB Survey).Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Melodie O AricòDepartment of Pediatrics, G. B. Morgagni-L. Pierantoni Hospital, AUSL Romagna, 47121 Forlì, Italy.
Francesco AccomandoDepartment of Pediatrics, G. B. Morgagni-L. Pierantoni Hospital, AUSL Romagna, 47121 Forlì, Italy.ORCID 0000-0002-3205-106X
Daniela TrottaPediatrics, S. Spirito Hospital, Azienda Sanitaria Locale Pescara, 65124 Pescara, Italy.
Anthea MarianiPediatrics, S. Spirito Hospital, Azienda Sanitaria Locale Pescara, 65124 Pescara, Italy.
Claudia RossiniPediatric Infectious Diseases, Children's Hospital Giovanni XXIII, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, 701243 Bari, Italy.
Claudio CafagnoPediatric Infectious Diseases, Children's Hospital Giovanni XXIII, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, 701243 Bari, Italy.ORCID 0000-0003-3951-1679
Letizia LorussoSchool of Medical Statistics and Biometry, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-2058-9284
Enrico VallettaDepartment of Pediatrics, G. B. Morgagni-L. Pierantoni Hospital, AUSL Romagna, 47121 Forlì, Italy.
Desiree CaselliPediatric Infectious Diseases, Children's Hospital Giovanni XXIII, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, 701243 Bari, Italy.ORCID 0000-0002-5716-3703
Maurizio AricòPediatrics, S. Spirito Hospital, Azienda Sanitaria Locale Pescara, 65124 Pescara, Italy.ORCID 0000-0002-1908-6671

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBronchiolitis accounts for a substantial number of pediatric hospitalizations and its epidemiology closely parallels that of respiratory syncytial virus (RSV), its principal etiological agent. International guidelines recommend supportive therapy based primarily on oxygen supplementation and hydration.

methodsThis study aimed to assess, across three pediatric wards, the impact of internal monitoring and targeted educational interventions on adherence to bronchiolitis management guidelines. Focus was placed on evaluating the effectiveness of tailored strategies in enhancing the appropriateness of treatment practices. Each center independently developed an audit and feedback strategy aligned with local practices and available resources. In Center 1, monthly staff meetings included guideline refreshers throughout the epidemic season. Center 2 appointed two attending physicians to monitor treatment prescriptions and report deviations. Center 3 established an internal protocol through staff consensus, followed by monthly review sessions. In this retrospective analysis, all consecutive patients admitted with bronchiolitis during the winter seasons of 2022-2023 and 2023-2024 (Period 2) were compared with those admitted in 2021-2022 (Period 1).

resultsA total of 623 infants under 24 months of age were included, 451 (72%) of whom tested positive for RSV. Their median length of hospital stay was 6 days; 26 infants (4%) required intensive care, and no deaths were recorded. A comparative analysis of the treatment modalities used-high-flow nasal cannula (HFNC) oxygen therapy, inhaled medications, corticosteroids, and antibiotics-revealed a reduced use of non-recommended therapies (e.g., nebulized β2-agonists, steroids, and antibiotics) in Period 2, alongside heterogeneous patterns in HFNC use. Center-specific strategies, tailored to team dynamics and resource availability, effectively promoted greater adherence to evidence-based guidelines.

conclusionsOur findings suggest that structured internal interventions can lead to more appropriate bronchiolitis management and the improved standardization of care.

Indexed as

antibioticsbronchiolitisguideline applicationHFNCsteroids

Identifiers

PMID40426750
PMCPMC12110107

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.