Evidence map›Paper›PMID 40426744›Full record

ArticleChildren (Basel, Switzerland)2025

Altered Brain Functional Connectivity and Topological Structural in Girls with Idiopathic Central Precocious Puberty: A Graph Theory Analysis Based on Resting-State fMRI.

Lu Tian, Yan Zeng, Helin Zheng, Jinhua Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lu TianDepartment of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing 400014, China.
Yan ZengDepartment of Endocrinology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing 400014, China.
Helin ZhengDepartment of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing 400014, China.
Jinhua CaiDepartment of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing 400014, China.ORCID 0000-0001-7971-8936

Funding

Chongqing Municipal Education Commission No.KJQN202300428
6 · The paper itself

Abstract

objectivesThis study aimed to investigate changes in brain functional connectivity (FC) and topological structure in girls with idiopathic central precocious puberty (ICPP) using complex network theory analysis.

methodsResting-state fMRI data from 53 ICPP girls (ages 6-8) and 51 controls were analysed. Graph theory was used to construct whole-brain functional networks, identify topological differences, and assess the relationship between sex hormone levels and network properties in regions with group differences.

resultsRS-FC analysis revealed reduced connectivity in cognitive and emotional regulation regions in the ICPP group (

conclusionsThis study highlights compensatory mechanisms in emotional regulation that may offset impairments in cognitive regions, offering new insights into ICPP's neural mechanisms.

Indexed as

brain functional connectivitycomplex networks graph theory analysisgirlidiopathic central precocious pubertytopological structural

Identifiers

PMID40426744
PMCPMC12110184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.