Evidence map›Paper›PMID 40426738›Full record

ReviewChildren (Basel, Switzerland)2025

Options for Regenerative Treatment with Bone Grafts in Children with Anterior Lip/Palate Cleft-A Review.

Anna Miguel-Escribano, Cosimo Galletti, Juan de Quixano-Bardaji, Francisco Real-Voltas, Luca Fiorillo, Maria Cuevas-Nunez, Fulvia Galletti, Javier Flores-Fraile

Abstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna Miguel-EscribanoDepartment of Integrated Dentistry, School of Dentistry, Universitat Internacional de Catalunya, 08195 Sant Cugat del Vallés, Spain.
Cosimo GallettiSchool of Medicine and Surgery Kore, University of Enna, 94100 Enna, Italy.ORCID 0000-0001-9938-4187
Juan de Quixano-BardajiDepartment of Integrated Dentistry, School of Dentistry, Universitat Internacional de Catalunya, 08195 Sant Cugat del Vallés, Spain.
Francisco Real-VoltasDepartment of Integrated Dentistry, School of Dentistry, Universitat Internacional de Catalunya, 08195 Sant Cugat del Vallés, Spain.ORCID 0000-0002-0805-5095
Luca FiorilloDepartment of Dental Cell Research, Dr. DY Patil Dental College and Hospital, Dr. DY Patil Vidyapeeth, Pune 411018, Maharashtra, India.ORCID 0000-0003-0335-4165
Maria Cuevas-NunezDepartment of Biomedical and Dental Science and Morphological and Functional Imaging, University of Messina, 98166 Messina, Italy.
Fulvia GallettiDepartment of Biomedical and Dental Science and Morphological and Functional Imaging, University of Messina, 98166 Messina, Italy.
Javier Flores-FraileDepartment of Surgery, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-1338-0551

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anterior lip/palate cleft is a congenital deformity affecting the upper lip and palate, posing significant challenges in both aesthetic and functional aspects for children. Effective management of this condition is crucial for improving quality of life and ensuring normal development. This review aims to highlight the regenerative treatment options available for children with anterior lip/palate cleft, focusing on the use of bone grafts and other advanced dental procedures. A review of the current literature and clinical practices was conducted to identify and evaluate the most effective treatment options. Emphasis was placed on regenerative techniques, particularly the use of bone grafts. Advancements in regenerative dentistry offer promising outcomes for children with anterior lip/palate cleft. Bone grafts, combined with innovative techniques such as growth factors, stem cell therapy, and distraction osteogenesis, provide effective solutions for restoring function and aesthetics. A multidisciplinary approach is essential to ensure comprehensive care and optimal results for these patients.

Indexed as

alveolar bone graftingbone graftcleft lipcleft palateembryologyepidemiologyetiologysecondary alveolar bone grafting

Identifiers

PMID40426738
PMCPMC12109887

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.