ArticleBrain sciences2025
Quantity and Quality Matter: Different Neuroanatomical Substrates of Apathy in Alzheimer's Disease and Behavioural Variant Frontotemporal Dementia.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundApathy is almost ubiquitous across neurodegenerative diseases and can be a general model for understanding neuropsychiatric symptoms in dementia.
methodsWe assessed apathy via Starkstein's Apathy Scale-caregiver version (SAS-C) in patients with Alzheimer's disease (AD) and behavioural variant frontotemporal dementia (bvFTD). Neuropsychological and structural neuroimaging data were also collected. Images were processed using the FreeSurfer program, and cortical thickness data were acquired for 68 brain regions.
resultsPatients with bvFTD had statistically higher levels of apathy than those with AD. The multivariate linear regression model found that the left entorhinal cortex (lEC) was the only region statistically associated with apathy in the AD group (F(1,31) = 5.17;
conclusionsThese results demonstrate that apathy is associated with multiple brain regions, reinforcing its multidimensionality and specific profiles.
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