Evidence map›Paper›PMID 40426498›Full record

ArticleAntibiotics (Basel, Switzerland)2025

Repurposing of Furin Inhibitors to Reduce Pathogenic

Isabella Rumer, Lilla Tóth, Annelie Wohlert, András Adorján, Ákos Jerzsele, Roman W Lange, Torsten Steinmetzer, Erzsébet Gere-Pászti

Abstract read
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In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isabella RumerDepartment of Pharmacology and Toxicology, University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary.
Lilla TóthDepartment of Pharmacology and Toxicology, University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary.
Annelie WohlertDepartment of Pharmacology and Toxicology, University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary.
András AdorjánDepartment of Microbiology and Infectious Diseases, University of Veterinary Medicine, Hungária krt. 23-25, H-1143 Budapest, Hungary.ORCID 0000-0002-2555-6123
Ákos JerzseleDepartment of Pharmacology and Toxicology, University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary.ORCID 0000-0002-3380-0827
Roman W LangeDepartment of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, 35032 Marburg, Germany.ORCID 0009-0004-7752-6403
Torsten SteinmetzerDepartment of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, 35032 Marburg, Germany.ORCID 0000-0001-6523-4754
Erzsébet Gere-PásztiDepartment of Pharmacology and Toxicology, University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary.

Funding

Recovery and Resilience Facility (RRF), financed under the National Recovery Fund RRF-2.3.1-21-2022-00001
6 · The paper itself

Abstract

BACKGROUND/

objectivesEnterobacteriaceae, including pathogenic

methodsTo assess the therapeutic potential of furin inhibitors, cultured epithelial cell models (IPEC-J2 and MDCK) were used. The effects of MI-1851 and MI-2415 were evaluated after short-term (2 h) and long-term (6 h) exposure to

resultsInfections with EHEC, EPEC, and

conclusionsThe development of new antimicrobial drugs that act via alternative mechanisms and effectively manage life-threatening enterobacterial infections is of key importance. Targeting furin with inhibitors MI-1851 and MI-2415, thus blocking toxin activation, could prevent the development of antimicrobial resistance, reduce the need for antibiotics and enhance overall treatment outcomes.

Indexed as

enterohemorrhagic E. colifurin inhibitorsinflammatory cytokinesIPEC-J2 cellsoxidative stressShiga toxinShigella flexneri

Identifiers

PMID40426498
PMCPMC12108508

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.