ArticleJournal of orthopaedic surgery and research2025
Clinical study on the impact of preoperative antibiotic administration timing on pus culture results in children with acute osteomyelitis.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Multicenter Retrospective Study of Musculoskeletal Bacterial Infections of the Pelvis in Children and Factors Associated With the Formation of an Abscess.The Pediatric infectious disease journal · 2026Observational
- Osteomyelitis.Nature reviews. Disease primers · 2026Review
- Bacterial pathogen spectrum and antimicrobial resistance in positive pus cultures from hospitalized patients at a maternal and child healthcare specialty hospital in Shenzhen, China, 2021-2025.Frontiers in cellular and infection microbiology · 2026Article
- Predictive Value ofDiagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to investigate the impact of preoperative antibiotic administration timing on pus culture results in children with acute osteomyelitis.
methodsClinical data of 87 children with acute osteomyelitis diagnosed and treated from January 2020 to July 2024 were retrospectively analyzed. All the children received antibiotic therapy prior to surgical debridement and drainage. During the surgical procedure, pus samples were collected for both standard bacterial culture and enrichment medium culture, and the enrichment medium culture yielded positive results in all cases. Based on the outcomes of the standard bacterial culture, 17 children with negative culture were classified into the negative group. 70 children with positive culture were assigned to the positive group.
resultsThere was no significant difference in gender between the two groups (P = 0.644). The age of the negative and positive group was 72.00 (39.50,90.00) months and 69.50 (25.50,108.00) months (P = 0.785), the duration of onset was 6.00 (4.00,9.50) days and 7.00 (4.00,7.00) days(P = 0.770), white blood cell counts were 14.23 (11.39,15.95)×10
conclusionsWhen antibiotics were administered for more than 3.5 days, the bacterial culture yield of pus decreased, and the standard bacterial culture was more likely to be negative.
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