Evidence map›Paper›PMID 40426245›Full record

ArticleBMC chemistry2025

Chemometrically assisted optimization and validation of the HPLC method for the analysis of alectinib and its related impurity with measurement uncertainty evaluation and whiteness, blueness, and greenness profile assessments.

Serkan Levent, Abeer Elriş, Hazal Avcı, Saniye Özcan, Nafiz Öncü Can

Abstract read
In one paragraph

Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Serkan LeventDepartment of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, Yunusemre Campus, 26470, Eskisehir, Turkey. serkanlevent@anadolu.edu.tr.ORCID http://orcid.org/0000-0003-3692-163X
Abeer ElrişDepartment of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, Yunusemre Campus, 26470, Eskisehir, Turkey.ORCID http://orcid.org/0000-0001-8467-478X
Hazal AvcıDepartment of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, Yunusemre Campus, 26470, Eskisehir, Turkey.ORCID http://orcid.org/0009-0000-8479-3615
Saniye ÖzcanDepartment of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, Yunusemre Campus, 26470, Eskisehir, Turkey.ORCID http://orcid.org/0000-0002-5492-0457
Nafiz Öncü CanDepartment of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, Yunusemre Campus, 26470, Eskisehir, Turkey.ORCID http://orcid.org/0000-0003-0280-518X

Funding

Anadolu Üniversitesi 2207S092
6 · The paper itself

Abstract

Alectinib, the most common second-generation anaplastic lymphoma kinase inhibitor, is efficacious against various anaplastic lymphoma kinase mutations and is utilized in the treatment of non-small cell lung cancer. In this work, the determination of both alectinib and its impurity 5-trifluoroacetate at the same time was realized by developing a novel high performance liquid chromatography method. The stationary phase was an Ascentis

Indexed as

AlectinibBox-BehnkenHPLCImpurity

Identifiers

PMID40426245
PMCPMC12117729

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.