Evidence map›Paper›PMID 40426242›Full record

ArticleVeterinary research2025

Host-similar fragments in the African swine fever virus genome: distribution, functions, and evolution.

Zhaozhong Zhu, Na Li, Qin Sun, Xizi Long, Tao Wang, Hua-Ji Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhaozhong ZhuSchool of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China. zzz2021@hnu.edu.cn.
Na LiSchool of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Qin SunSchool of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Xizi LongSchool of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Tao WangState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-Reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Hua-Ji QiuState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-Reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China. qiuhuaji@caas.cn.ORCID http://orcid.org/0000-0003-4880-5687

Funding

National Natural Science Foundation of China U20A2060Natural Science Foundation of Heilongjiang Province TD2023C007PhD Scientific Research Start-up Fund of the University of South China 5524QD075
6 · The paper itself

Abstract

African swine fever virus (ASFV) predominantly infects Argasidae and suids, resulting in high morbidity and mortality in pigs. Despite the crucial role that viral sequences resembling those of the host play in the virus's survival, there are limited comprehensive studies on the genomic similarities between ASFV and its hosts. Consequently, this study employs homology analysis to construct a similarity network between ASFV and its hosts (Argasidae and suids), investigating the distribution, function, evolution, and origins of these similar sequences in ASFV. Our findings indicate that the host-similar fragments are mainly distributed between positions 70000 and 180000 of the ASFV genome, primarily within non-coding regions. Notably, these non-coding fragments are often associated with promoter functions. Furthermore, the analysis of suid proteins that share similarities with ASFV proteins reveals that they predominantly exhibit RNA polymerase activity and are involved in metabolic processes. Evolutionary analysis indicates that pan-similar sequences of ASFV exist in an open state, highlighting the diversity of these analogous sequences. Additionally, a positive correlation was identified between the occurrence of recombination breakpoints and similar sequences, indicating that homologous recombination may serve as a crucial mechanism driving the formation of these analogous sequences.

Indexed as

African Swine FeverAfrican Swine Fever VirusGenome, ViralOrnithodorosAnimalsEvolution, MolecularPhylogenySwineAfrican swine fever virusevolutionhost-similar fragmentsrecombinationsimilarity network

Identifiers

PMID40426242
PMCPMC12107907

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.