Evidence map›Paper›PMID 40426035›Full record

ArticleBMC cardiovascular disorders2025

Exposure to perchlorate, nitrate and thiocyanate was associated with the prevalence of hypertension.

Xiaofan Miao, Yan Chen, Jingping Lu, Hongjian Shan, Ran Chen

Erratum issuedAbstract read
In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Xiaofan MiaoDepartment of Cardiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Yan ChenDepartment of Cardiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Jingping LuDepartment of Cardiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Hongjian ShanDepartment of Orthopedics, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China. 1638984763@qq.com.
Ran ChenDepartment of Cardiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. chenran000963@163.com.

Funding

2024 Nanjing Medical University Science and Technology Development Fund Project NMUB2024110
6 · The paper itself

Abstract

backgroundOur study aims to examinate the relationships between exposure to perchlorate, nitrate, and thiocyanate and the risk of hypertension.

methodsA total of 21,321 participants were selected from the National Health and Nutritional Examination Survey (NHANES). We used logistic regressions models to explore the odds ratio of urinary perchlorate, nitrate, and thiocyanate on the risk of hypertension and restricted cubic splines to check the nonlinearity.

results2851 (13.4%) individuals were diagnosed with hypertension. Multivariable logistic regression analysis suggested that urinary perchlorate and nitrate were inversely associated with hypertension, and thiocyanate has a positive correlation. Compared with the lowest quartile, the highest quartile of odds ratios was 0.86 (0.74-1.00; P = 0.048) for perchlorate, 0.79 (0.67-0.94; P = 0.007) for nitrate, and 1.47 (1.25-1.73; P < 0.001) for thiocyanate. Restricted cubic splines showed that urinary perchlorate was nonlinearly associated with hypertension (P = 0.0014).

conclusionsHigher exposure to perchlorate and nitrate were associated with a lower risk of hypertension, while a positive association was observed for urinary thiocyanate.

Indexed as

Blood PressureEnvironmental ExposureHypertensionNitratesPerchloratesThiocyanatesAdultAgedBiomarkersCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysPrevalenceBiomarkersNitratesperchloratePerchloratesthiocyanateThiocyanatesHypertensionNHANESNitratePerchlorateThiocyanate

Identifiers

PMID40426035
PMCPMC12107915

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.