SynthesisBMC cardiovascular disorders2025
A meta-analysis on the safety and accuracy of the HEART pathway for risk stratification in patients with acute chest pain.
Synthesis in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Large language models for acute coronary syndrome triage at first medical contact in emergency departments.NPJ digital medicine · 2026Article
- Optimizing Acute Chest Pain Management: Navigating Diagnostic Challenges and Advancing Precision Care.Reviews in cardiovascular medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThe HEART Pathway is used for the rapid assessment of acute chest pain patients and identification of high-risk patients. However, there is no consensus regarding the safety and accuracy of HEART Pathway in stratifying risk in chest pain patients. The present work focused on systematically assessing the effectiveness and safety of the HEART Pathway in stratifying risk of acute chest pain patients.
methodsWeb of Science, PubMed, Cochrane Library, Embase, and CNKI were thoroughly searched up to May 30, 2024, for relevant studies on HEART Pathway for stratifying risk among acute chest pain patients. Two independent researchers screened the literatures, extracted the data, and performed a meta-analysis using Stata/MP 16.0.
resultsThere were altogether 10 articles being enrolled. HEART Pathway demonstrated combined sensitivity, specificity, diagnostic odds ratio, positive and negative diagnostic likelihood ratios of 0.97 [95% CI (0.95, 0.98)], 0.47 [95% CI (0.40, 0.55)], 27.34 [95% CI (18.22, 41.04)], 1.83 [95% CI (1.60, 2.09)], and 0.07 [95% CI (0.04, 0.10)], separately. In addition, the area under the summary receiver operating characteristic curve was 0.91 [95% CI (0.88, 0.93)].
conclusionThe HEART Pathway efficiently triages patients who have a low chest pain risk while ensuring the high safety level, emphasizing its significant clinical applicability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.