Evidence map›Paper›PMID 40426021›Full record

ArticleAutophagy2025

ATG5 controls CD80 expression in B cells and shapes cognate CD4

Ingredy Passos, Thomas Zobel, Christian Münz, Anneli Peters, Jan D Lünemann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ingredy PassosDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, North Rhine-Westphalia, Germany.
Thomas ZobelMünster Imaging Network, Cells in Motion Interfaculty Centre, University of Münster, Münster, North Rhine-Westphalia, Germany.
Christian MünzViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zurich, Switzerland.
Anneli PetersInstitute of Clinical Neuroimmunology, University Hospital Ludwig-Maximilians-Universität München, Bavaria, Germany.
Jan D LünemannDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, North Rhine-Westphalia, Germany.ORCID 0000-0002-3007-708X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The macroautophagy/autophagy machinery has been implicated in supporting MHC class II but compromising MHC class I restricted antigen presentation by dendritic cells (DCs). Here, we report that loss of the essential autophagy protein ATG5 in B cells reduces internalization and stabilizes co-stimulatory CD80 surface expression. In an adjuvant-free experimental autoimmune encephalomyelitis (EAE) mouse model, co-transfer of MOG-specific induced germinal center B (iGB) cells deficient in ATG5 with MOG-specific CD4

Indexed as

Autophagy-Related Protein 5B7-1 AntigenB-LymphocytesCD4-Positive T-LymphocytesAnimalsAntigen PresentationAutophagyDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalGerminal CenterLymphocyte ActivationMiceMice, Inbred C57BLMyelin-Oligodendrocyte GlycoproteinAtg5 protein, mouseAutophagy-Related Protein 5B7-1 AntigenMyelin-Oligodendrocyte GlycoproteinAntigen presentationautoimmunityautophagy proteinsB- and T-cell interactioncentral nervous systemmultiple sclerosis

Identifiers

PMID40426021
PMCPMC12459358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.