Evidence map›Paper›PMID 40425993›Full record

ArticleGeneral thoracic and cardiovascular surgery2025

A nation-wide survey of myocardial protection in cardiovascular surgery.

Hideki Yotsuida, Tomoyuki Fujita, Hiroshi Yamamoto, Minoru Ono, Noboru Motomura, Aya Saito, Yuji Hiramatsu, Hirotsugu Fukuda, Takako Miyazaki, Yuko Wada and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in General thoracic and cardiovascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hideki YotsuidaDepartment of Clinical Engineering, National Hospital Organization Osaka National Hospital, Osaka, Japan.
Tomoyuki FujitaDepartment of Cardiovascular Surgery, Institute of Science Tokyo, Tokyo, Japan.
Hiroshi YamamotoDepartment of Cardiovascular Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Minoru OnoDepartment of Cardiovascular Surgery, The University of Tokyo, Tokyo, Japan.
Noboru MotomuraDepartment of Cardiovascular Surgery, Toho University Sakura Medical Center, Sakura, Japan.
Aya SaitoDepartment of Surgery, Yokohama City University, Graduate School of Medecine, Yokohama, Japan.
Yuji HiramatsuDepartment of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan.
Hirotsugu FukudaDepartment of Cardiovascular Surgery, Dokkyo Medical University, Mibu, Japan.
Takako MiyazakiDepartment of Cardiovascular Surgery, Otsu City Hospital, Otsu, Japan.
Yuko WadaDepartment of Cardiovascular Surgery, Shinshu University, Matsumoto, Japan.
Yoshiki SawaDepartment of Cardiovascular Surgery (President), Osaka Keisatsu Hospital, Osaka, Japan.
Hitoshi OginoDepartment of Cardiovascular Surgery, Medical Research Institute Kitano Hospital, 2-4-20 Ohgimachi Kita-Ku, Osaka, 530-8480, Japan. h-ogino@kitano-hp.or.jp.ORCID http://orcid.org/0000-0001-8622-7828

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA nationwide questionnaire survey was conducted by the Research and Education Committee of the Japanese Association for Thoracic Surgery to investigate current practices of myocardial protection using cardioplegia (CP) in cardiovascular surgery, with the aim of developing a recommendation statement on CP.

methodsThe survey was sent to 521 facilities and focused on adult cardiac surgery (ACS), aortic surgery (AS), and pediatric cardiac surgery (PCS). The response rate was 86.0%, with 448 institutions participating.

resultsAmong the participating hospitals, 64.3% used blood CP (BCP), 22.5% crystalloid CP (CCP), and 13.2% a combination of both. In CCP, the most common base solution was Miotector®, an extracellular fluid. In approximately half of the cases where CCP was used initially, BCP was employed for subsequent infusions. In BCP, a customized or modified version of Miotector® was also used as the base solution in over 50% of the cases. The ratio of blood to crystalloid solutions varied across institutions. For both forms of CP, the initial infusion volumes were typically around 20 ml/kg, with subsequent infusions averaging 10 ml/kg. A combined antegrade and retrograde CP infusion method was preferred by most institutions, and terminal warm CP was used in approximately 75% of institutions. Notably, the CP techniques used in minimally invasive cardiac surgery were consistent with those used in conventional surgery via median sternotomy.

conclusionsThis survey provides valuable insights into the diverse practices of myocardial protection, highlighting the need for further comprehensive studies to develop standardized guidelines for CP in cardiovascular surgery.

Indexed as

Cardiac Surgical ProceduresCardioplegic SolutionsHeart Arrest, InducedPractice Patterns, Physicians'Health Care SurveysHumansJapanTreatment OutcomeCardioplegic SolutionsCardioplegiaCardiovascular surgeryMyocardial protectionNationwide questionnaire survey

Identifiers

PMID40425993

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.