Evidence map›Paper›PMID 40425928›Full record

ArticleJournal of cardiovascular translational research2025

Randomised Comparison of Culotte- versus Double Kissing Crush Stenting in de novo non-left Main Coronary Bifurcation Lesions: Rationale and Design of the Bifurcation Bad Krozingen trial-3 (BBK-3).

Faridun Rahimi, Nikolaus Löffelhardt, Jan Minners, Philipp Breitbart, Kilian Franke, Tau Sarra Hartikainen, Christian Valina, Constantin V Zur Mühlen, Thomas Nührenberg, Adnan Kastrati and 9 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04192760 (Bifurcations Bad Krozingen), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04192760 naunknown statusnot on this map

Bifurcations Bad Krozingen (BBK) 3 - Trial Randomised Comparison of Culotte-stenting Versus DK-Crush--stenting for the Treatment of de Novo Non-left Main Coronary Bifurcation Lesions With Everolimus-eluting Stents

TypeinterventionalSponsorUniversity Heart Center Freiburg - Bad KrozingenRan2019 to 2023Enrolled400ConditionsCoronary Stenosis, Stent StenosisArmsStenting
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Faridun RahimiDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany. Faridun.rahimi@uniklinik-freiburg.de.ORCID 0009-0008-3553-9088
Nikolaus LöffelhardtDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Jan MinnersDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Philipp BreitbartDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Kilian FrankeDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Tau Sarra HartikainenDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Christian ValinaDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Constantin V Zur MühlenDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Thomas NührenbergDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Adnan KastratiDepartment of Cardiology, Technische Universitaet Muenchen, Deutsches Herzzentrum Muenchen, Munich, Germany.
Felix WoitekDepartment of Internal Medicine and Cardiology, Heart Center Dresden, University Hospital, Technische Universität Dresden, Dresden, Germany.
Albrecht ElsaesserHeart-Circulation Centre, Clinic Oldenburg, Oldenburg, Germany.
Mohamed Abdel-WahabHeart Center Leipzig, University of Leipzig, Leipzig, Germany.
Samuel SossallaDepartment of Cardiology, University Hospital Giessen Kerckhoff Clinic, Giessen, Germany.
Willibald HochholzerDepartment of Cardiology and Intensive Care Medicine, Klinikum Wuerzburg Mitte, Würzburg, Germany.
Dirk WestermannDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Franz-Josef NeumannDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Christoph OlivierDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.
Miroslaw FerencDepartment of Cardiology and Angiology, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Suedring 15, 79189, Bad Krozingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whether culotte or double kissing (DK)-crush stenting is the superior systematic 2-stent technique in non-left main bifurcation lesions is unclear. The BBK-3 (unique identifier NCT04192760) is a multicenter, prospective, randomized controlled trial to test the hypothesis that culotte stenting reduces maximal percent diameter restenosis at 9-month follow-up compared to DK-crush stenting in de-novo non-left main coronary bifurcation lesions using approved, third-generation drug-eluting stents (DES). A total of 400 patients will be randomized in a 1:1 ratio to receive a two-stent strategy. The primary study endpoint is the maximal percent diameter in-stent restenosis within the bifurcation at 9 months, assessed by quantitative coronary angiography. Secondary endpoints include target lesion revascularization (TLR), the composite of death and myocardial infarction, emergent cardiac bypass surgery and TLR (MACE) at 12 months. BBK-3 will assist in the identification of the preferable, contemporary 2-stent strategy in the treatment of de-novo non-left main coronary bifurcation lesions.

Indexed as

Coronary Artery DiseaseDrug-Eluting StentsPercutaneous Coronary InterventionAgedCoronary AngiographyCoronary RestenosisFemaleHumansMaleMiddle AgedMulticenter Studies as TopicProspective StudiesProsthesis DesignRandomized Controlled Trials as TopicRisk FactorsTime Factors2-stent strategyBifurcationCulotteDK-crushPCI

Identifiers

PMID40425928
PMCPMC12436574

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.