Evidence map›Paper›PMID 40425892›Full record

ArticleInsights into imaging2025

Inter- and intra-observer variability of software quantified bowel motility measurements of small bowel Crohn's disease: findings from the MOTILITY trial.

Maira Hameed, Andrew A Plumb, Kashfia Chowdhury, Norin Ahmed, Safi Rahman, Gauraang Bhatnagar, Elen Thomson, Maryam Mohsin, Jude Holmes, Steve Halligan and 2 more

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In one paragraph

Article in Insights into imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maira HameedDepartment of Radiology, University College London Hospitals, London, NW1 2BU, UK.
Andrew A PlumbDepartment of Radiology, University College London Hospitals, London, NW1 2BU, UK.
Kashfia ChowdhuryComprehensive Clinical Trials Unit, University College London, London, WC1V 6LJ, UK.
Norin AhmedComprehensive Clinical Trials Unit, University College London, London, WC1V 6LJ, UK.
Safi RahmanDepartment of Radiology, Epsom and St Helier University Hospitals NHS Trust, Epsom, KT18 7EG, UK.
Gauraang BhatnagarCentre for Medical Imaging, University College London, London, W1W 7TS, UK.
Elen ThomsonDepartment of Radiology, St James's University Hospital, Leeds, LS9 7TF, UK.
Maryam MohsinDepartment of Radiology, St James's University Hospital, Leeds, LS9 7TF, UK.
Jude HolmesCentre for Medical Imaging, University College London, London, W1W 7TS, UK.
Steve HalliganDepartment of Radiology, University College London Hospitals, London, NW1 2BU, UK.
Stuart A TaylorDepartment of Radiology, University College London Hospitals, London, NW1 2BU, UK. stuart.taylor@ucl.ac.uk.ORCID http://orcid.org/0000-0002-6765-8806
MOTILITY trial investigators

Funding

Efficacy and Mechanism Evaluation Programme NIHR EME 14/201/16
6 · The paper itself

Abstract

objectivesMotility magnetic resonance imaging (mMRI) is a potential marker of disease activity of small bowel Crohn's disease (SBCD), but there is limited data on its reproducibility. We assessed inter- and intra-observer agreement of small bowel motility as part of a prospective multicentre trial investigating whether mMRI can predict longer-term response to biologic therapy in active, non-stricturing SB-CD (MOTILITY Trial).

methods297 segmental small bowel motility scores from 104 SBCD patients (mean age 38.9 years, 43 female) recruited to the MOTILITY trial were measured independently by two radiologists experienced in mMRI, using GIQuant software. Twenty-six datasets were re-read by both radiologists to test intra-observer variability after a washout period of at least 6 weeks. Five gastrointestinal radiologists inexperienced in mMRI derived 66 segmental motility scores from the same 30 randomly selected patients. Agreement was quantified using the intra-class correlation coefficient (ICC).

resultsThere was moderate agreement for mMRI-derived segmental small bowel motility measurements for both mMRI-experienced and inexperienced radiologists (ICC 0.59 (95% CI: 0.51, 0.66) and 0.70 (95% CI: 0.61, 0.78), respectively). Agreement remained moderate to good, combining the experienced trial MRI reader measurements with those of the five inexperienced radiologists (ICC 0.69 (95% CI: 0.61, 0.78). Intra-observer agreement for the two mMRI experienced radiologists was (0.71 (95% CI: 0.44, 0.86) and 0.70 (95% CI: 0.44, 0.86)).

conclusionsThere is moderate to good interobserver agreement for mMRI measurements of segmental small bowel motility for both experienced and inexperienced radiologists. CRITICAL RELEVANCE STATEMENT: Study findings support the continuing clinical translation of motility MRI as a reproducible biomarker of disease activity and treatment response in Crohn's disease. KEY POINTS: Motility MRI is a novel biomarker of small bowel Crohn's disease activity. Currently, limited data on intra- and inter-observer variability exists. Motility MRI shows moderate to good inter- and intra-observer agreement. Intraclass correlation was 0.59-0.71 for experienced and inexperienced radiologists. Motility MRI is reproducible, supporting its utility as a biomarker of disease activity.

Indexed as

BiomarkersCrohn diseaseGastrointestinal motilityMagnetic resonance imagingObserver variation

Identifiers

PMID40425892
PMCPMC12116975

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