Evidence map›Paper›PMID 40425841›Full record

ArticleNature medicine2025

Patient-centered integration of tumor and germline genetic results can improve cancer care.

Alanna J Church, Oindrila Bhattacharyya, Julie O Culver, Yonatan Amzaleg, Erin Linnenbringer, Maeve Smart, Christina Ip-Toma, Adan Reinosa Rivera, Bethany Davis, Charité Ricker and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alanna J ChurchDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. alanna.church@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-4835-5770
Oindrila BhattacharyyaDepartment of Biomedical Informatics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Julie O CulverUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yonatan AmzalegDepartment of Integrative Translational Science, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Erin LinnenbringerDepartment of Surgery, School of Medicine, Washington University, St. Louis, MO, USA.
Maeve SmartDana-Farber Cancer Institute, Boston, MA, USA.
Christina Ip-TomaMIB Agents Osteosarcoma Alliance, Barnard, VT, USA.
Adan Reinosa RiveraUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Bethany DavisClinical Genomics and Therapeutic Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Charité RickerUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Heinz-Josef LenzUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2178-9568
Stacy W GrayDepartment of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Heather Hampel *Division of Clinical Cancer Genomics, Department of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-7558-9794
David W Craig *Department of Integrative Translational Science, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-2040-1955

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
USC PE-GCS: Optimizing Engagement of Hispanic Colorectal Cancer Patients in Cancer Genomic Characterization StudiesU2CCA252971 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JOHN D. CARPTEN, HEINZ JOSEF LENZ · 2021 to 2026
$19.3M
Participant Engagement and Cancer Genome Sequencing (PE-CGS): Coordinating CenterU24CA252977 · NCI · OHIO STATE UNIVERSITY · PI BRIDGES, JOHN F., KIM, HYOSHIN · 2020 to 2024
$2.5M
NCI NIH HHS P30 CA014089NCI NIH HHS U24 CA252977NCI NIH HHS U2C CA252971
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40425841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.