ArticleNature immunology2025
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections.
Abstract read
In one paragraph
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- JN.1-adapted vaccination is associated with readjustment of ancestral memory B cells toward neutralization within the JN.1 antigenic space.Nature communications · 2026Article
- Intranasal boosting induces variant-specific responses in SARS-CoV-2 vaccine-imprinted mice.Nature communications · 2026Article
- Oriented Multivalent Display Drives Consistent Serum Immunodominance to the Ebola Virus Glycoprotein.ACS central science · 2026Article
- COVID-19 mRNA vaccines: a prospective outlook from technological innovation to clinical practice.Frontiers in immunology · 2026Review
- Immunogenicity of monovalent and multivalent subunit vaccines against SARS-CoV-2 variants in mice with divergent vaccination history.Microbiology spectrum · 2025Article
Corrections and comments
- Update ofDeterminants of2023
Authors and funding
29 authors.
Grace E QuirkDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0009-0006-3327-1511
Marta V SchoenleDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA.
Kameron L PeytonDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA.
Jennifer L UhrlaubDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA.
Branden LauUniversity of Arizona Genomics Core and the Arizona Research Labs, University of Arizona Genetics Core, University of Arizona, Tucson, AZ, USA.
Chieh-Yu LiangDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-4624-7212
Jefferey L BurgessMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0003-2362-9509
Katherine EllingsonDepartment of Epidemiology and Biostatistics, Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Shawn BeitelMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
James RomineMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Karen LutrickCollege of Medicine-Tucson, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0003-3480-849X
Ashley FowlkesNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Amadea BrittonNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Harmony L TynerSt. Luke's Regional Health Care System, Duluth, MN, USA.
Alberto J Caban-MartinezDepartment of Public Health Services, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID http://orcid.org/0000-0002-5960-1308
Allison NalewayKaiser Permanente Northwest Center for Health Research, Portland, OR, USA.
Manjusha GaglaniTexas A&M University College of Medicine, Temple, TX, USA.ORCID http://orcid.org/0000-0002-3952-9230
Sarang YoonRocky Mountain Center for Occupational and Environmental Health, Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City, UT, USA.
Laura J EdwardsAbt Associates, Rockville, MD, USA.
Lauren OlshoAbt Associates, Rockville, MD, USA.ORCID http://orcid.org/0000-0003-4503-9745
Michael DakeOffice of the Senior Vice-President for Health Sciences, University of Arizona, Tucson, AZ, USA.
Riccardo ValdezDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Aubree GordonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9352-7877
Michael S DiamondDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-8791-3165
Bonnie J LaFleurBIO5 Institute, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0002-4939-9337
Janko Ž NikolichDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA.
Ryan SprisslerUniversity of Arizona Genomics Core and the Arizona Research Labs, University of Arizona Genetics Core, University of Arizona, Tucson, AZ, USA.
Michael WorobeyDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA.
Deepta BhattacharyaDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA. deeptab@arizona.edu.ORCID http://orcid.org/0000-0001-8377-7699
Funding
COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4MNIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00015 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HENSLEY, SCOTT · 2021 to 2025
$50.7MCTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9MTRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITYR01AI099108 · NIAID · WASHINGTON UNIVERSITY · PI Deepta Bhattacharya · 2012 to 2026
$6.4MHuman antibody-based countermeasures against the Wuhan Coronavirus SARS-CoV-2R01AI157155 · NIAID · WASHINGTON UNIVERSITY · PI BARIC, RALPH S, CROWE, JAMES E · 2020 to 2024
$6.0MGLUCOSE AND AMINO ACID CATABOLISM IN PLASMA CELL BIOLOGYR01AI129945 · NIAID · UNIVERSITY OF ARIZONA · PI Deepta Bhattacharya · 2018 to 2026
$4.8MCDC HHS 75D30120C08150CDC HHS 75D30120C08379NCATS NIH HHS UM1 TR004409NIAID NIH HHS 75N93019C00051NIAID NIH HHS 75N93021C00015NIAID NIH HHS R01 AI099108NIAID NIH HHS R01 AI129945NIAID NIH HHS R01 AI157155U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI099108U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI129945U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI157155
Abstract
Few type-specific antibodies that recognize drifted epitopes are made during post-vaccination exposures to SARS-CoV-2 variants
Indexed as
Antibodies, ViralCOVID-19COVID-19 VaccinesImmunogenicity, VaccineSARS-CoV-2AdultAntibodies, NeutralizingB-LymphocytesEpitopes, B-LymphocyteFemaleHumansImmunologic MemoryMaleMemory B CellsMiddle AgedSpike Glycoprotein, CoronavirusAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesEpitopes, B-LymphocyteSpike Glycoprotein, Coronavirus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.