Evidence map›Paper›PMID 40425766›Full record

ArticleScientific reports2025

Nonlinear relationship between serum high sensitivity C reactive protein to high density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease.

Yanyan Xuan, Bujiang Wang, Binhua Xie, Yuanyuan Cen, Songping Yu, Qi Yao

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanyan XuanDepartment of Hospital Infection, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. 13566020545@163.com.
Bujiang WangDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Binhua XieDepartment of Rheumatology Immunology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Yuanyuan CenDepartment of Respiratory and Critical Care Medicine, Cixi Longshan Hospital, Ningbo, Zhejiang, China.
Songping YuDepartment of Geriatrics Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Qi YaoDepartment of Geriatrics Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. nbdxdyyy@163.com.

Funding

Medical Health Science and Technology Project of Zhejiang Provincial Health Commission Grant No. 2025KY1377
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) has become an increasing public health concern. We examined the association between serum high-sensitivity C-reactive protein(hs-CRP)to high-density lipoprotein cholesterol (HDL-C) ratio (HCHR) and the prevalence of NAFLD, extent of hepatic steatosis and fibrosis in the general US population. This cross-sectional analysis included 4039 adult participants from the 2017 to 2018 National Health and Nutrition Examination Survey. Multivariable logistic regression and multivariable linear regression analyses were used to assess the association between HCHR levels and NAFLD, fatty liver degree, and liver fibrosis. Generalized additive models examined the nonlinear relationship between the HCHR and NAFLD. In the three models, HCHR was positively associated with NAFLD, model 1 (OR  1.315, 95% CI 1.273, 1.359), model 2 (OR 1.364, 95% CI 1.317, 1.412) and model 3 (OR  1.120, 95% CI 1.074, 1.168). Stratified analyses showed that the association was more prominent in women, those younger than 40 years, Mexican-Americans, and those with a 25-30 kg/m

Indexed as

Cholesterol, HDLC-Reactive ProteinNon-alcoholic Fatty Liver DiseaseAdultBiomarkersCross-Sectional StudiesFemaleHumansLiver CirrhosisMaleMiddle AgedNutrition SurveysPrevalenceRisk FactorsUnited StatesBiomarkersCholesterol, HDLC-Reactive ProteinFibrosisHDL-CHigh-sensitivity C-reactive proteinNAFLDSteatosis

Identifiers

PMID40425766
PMCPMC12116901

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.