Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis.

Manisha A Patel, Vandana Sharma, Rupali Chavan, Juhi Pal, Santosh J Gharpure, Anant R Kapdi

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Manisha A PatelDepartment of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai, 400019, India.

Vandana SharmaDepartment of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai, 400019, India.

Rupali ChavanDepartment of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.

Juhi PalDepartment of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.

Santosh J GharpureDepartment of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.

Anant R KapdiDepartment of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai, 400019, India. ar.kapdi@ictmumbai.edu.in.

Funding

Science and Engineering Research Board CRG/2023/0000045

6 · The paper itself

Abstract

S-methyl thioesters have proven to be useful intermediates in many biosynthetic reactions and their occurrence in bioactive molecules further enhance their appeal. Shortcomings in several reported synthetic protocols have led us to disclose herewith a mild, room temperature ex situ protocol that provides access to a large number of thioesters (aryl, heteroaryl, alkyl, amino acids). Late-stage functionalization strategies were also performed on commercial pharmaceutical drugs (containing carboxylic acid functionality) while further in situ conversion to valuable compounds has also been achieved.

Identifiers

PMID40425747

DOI10.1038/s41598-025-97728-3

PMCPMC12117044

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.