Evidence map›Paper›PMID 40425699›Full record

ArticleScientific reports2025

Pre conception dyslipidemia and risk for preeclampsia in women undergoing IVF ET.

Shaomin Chen, Yang Wang, Zhaoyu Wang, Liyuan Tao, Yongqing Wang, Yuan Wei, Zhaoping Li, Rong Li

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaomin Chen *Department of Cardiology, Institute of Vascular Medicine, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Ministry of Health, Ministry of Education, Beijing, 100191, China.
Yang Wang *Center for Reproductive Medicine, Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Key Laboratory of Assisted Reproduction (Peking University), Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Peking University Third Hospital), Ministry of Education, Beijing, 100191, China.
Zhaoyu WangResearch Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, 100191, China.
Liyuan TaoResearch Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, 100191, China.
Yongqing WangDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.
Yuan WeiDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.
Zhaoping LiDepartment of Cardiology, Institute of Vascular Medicine, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Ministry of Health, Ministry of Education, Beijing, 100191, China. zhaoping1223@163.com.
Rong LiCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Key Laboratory of Assisted Reproduction (Peking University), Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Peking University Third Hospital), Ministry of Education, Beijing, 100191, China. roseli001@sina.com.

Funding

the Key clinical projects of the Peking University Third Hospital BYSYZD2021014
6 · The paper itself

Abstract

This study investigated the relationship between dyslipidemia prior to conception and the risk of preeclampsia (PE) in women pregnant by in vitro fertilization and embryo transfer (IVF-ET). The retrospective cohort study consisted of 2994 women who conceived by IVF-ET and delivered live neonates. The study population was divided into two components: a training set for the prediction model development (2288 women) and a test set for validation (706 women). Multivariable logistic regression was used for the development and validation of predictive model for the risk of PE. Among the 2288 women in the training set, 266 women (11.6%) developed PE. Multiple logistic regression analysis identified independent predictors for PE: triglyceride (TG) [adjusted odds ratio (aOR) 1.284; 95% confidence interval (CI) 1.113-1.489, P < 0.001]; pre-pregnancy BMI; pre- chronic hypertension; twin pregnancy; embryo transfer protocol. These independent predictors for PE were used to form a risk prediction model, and the area under the receiver-operator characteristic (ROC) curve (AUC) in the training and the test set was 0.77 (95% CI 0.73-0.80)and 0.71 AUC (95% CI 0.65-0.77), respectively. In conclusion, higher TG levels before pregnancy were independently associated with the risk for PE in women pregnant by IVF-ET.

Indexed as

DyslipidemiasEmbryo TransferFertilization in VitroPre-EclampsiaAdultFemaleHumansPregnancyRetrospective StudiesRisk FactorsROC CurveTriglyceridesTriglyceridesDyslipidemiaIn vitro fertilization and embryo transferPrediction modelPreeclampsia

Identifiers

PMID40425699
PMCPMC12116852

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.