Evidence map›Paper›PMID 40425656›Full record

ArticleScientific reports2025

Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing.

Jingjing Wang, Lin Ji, Yingbo Gao, Jingyu Sun, Xiaobin Zhou, Yujia Ding, Zihan Zhou, Xiaofan Guo, Chao Liu, Yujie Wang and 3 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Anti-Inflammatory Evaluation of Pyrazino[2,1-Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jingjing Wang *Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, and Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Lin Ji *Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, and Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Yingbo GaoDepartment of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, and Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Jingyu SunDepartment of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, and Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Xiaobin ZhouDepartment of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, and Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Yujia DingDepartment of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, and Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Zihan ZhouDepartment of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, and Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Xiaofan GuoDepartment of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, and Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Chao LiuDepartment of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, and Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Yujie WangThe Fourth Department of Bone Injury, The First Affiliated Hospital of Hebei University of Traditional Chinese Medicine, Shijiazhuang, 050011, China.
Qingfu ZhangBurn and Wound Repair Center, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
Zhenmu LvBurn and Wound Repair Center, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China. lvzhenmu@126.com.
Dong MaDepartment of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, and Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, 050017, Hebei, China. madong119@hebmu.edu.cn.

Funding

Natural Science Foundation of Hebei Province of China H2022423343The Government-funded Project for Training Outstanding Clinical Medical Talents by the Health Commission of Hebei Province No. 2021379
6 · The paper itself

Abstract

Cyclin-dependent kinase 5 (CDK5) plays a critical role in the inflammatory response. Macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. However, the effectiveness of CDK5 in macrophages on cutaneous wound healing remains inadequately characterized. We determined the role of CDK5 signaling pathway in macrophages in mouse cutaneous wound healing through the established macrophage-specific deletion of CDK5 (myeCDK5

Indexed as

Cyclin-Dependent Kinase 5InflammationMacrophagesSignal TransductionSkinWound HealingAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutPhosphorylationRoscovitineSirtuin 1Cdk5 protein, mouseCyclin-Dependent Kinase 5RoscovitineSirt1 protein, mouseSirtuin 1Cutaneous wound healingCyclin-dependent protein kinase 5MacrophagesPhenotypic transformationSilent information regulator Sirtuin 1

Identifiers

PMID40425656
PMCPMC12116921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.