Evidence map›Paper›PMID 40425649›Full record

ArticleScientific data2025

PathoGraph: A Graph-Based Method for Standardized Representation of Pathology Knowledge.

Peiliang Lou, Yuxin Dong, Caixia Ding, Chunbao Wang, Ruifeng Guo, XiaoBo Pang, Chen Wang, Chen Li

Abstract readDataset
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peiliang LouSchool of Computer Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.ORCID http://orcid.org/0000-0002-6683-0256
Yuxin DongSchool of Computer Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.
Caixia DingDepartment of Pathology, Shaanxi Provincial Tumor Hospital, Xi'an Jiaotong University, 309 Yanta West Road, Xi'an, Shaanxi, China.
Chunbao WangDepartment of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi, China.
Ruifeng GuoDivision of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.ORCID http://orcid.org/0000-0003-3345-0502
XiaoBo PangSchool of Computer Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.
Chen WangDivision of Computational Biology, Mayo Clinic, Rochester, MN, USA. wang.chen@mayo.edu.ORCID http://orcid.org/0000-0003-2638-3081
Chen LiNational Engineering Lab for Big Data Analytics, Xi'an Jiaotong University, Xi'an, Shaanxi, China. cli@xjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathology data, primarily consisting of slides and diagnostic reports, inherently contain knowledge that is pivotal for advancing data-driven biomedical research and clinical practice. However, the hidden and fragmented nature of this knowledge across various data modalities not only hinders its computational utilization, but also impedes the effective integration of AI technologies within the domain of pathology. To systematically organize pathology knowledge for its computational use, we propose PathoGraph, a knowledge representation method that describes pathology knowledge in a graph-based format. PathoGraph can represent: (1) pathological entities' types and morphological features; (2) the composition, spatial arrangements, and dynamic behaviors associated with pathological phenotypes; and (3) the differential diagnostic approaches used by pathologists. By applying PathoGraph to neoplastic diseases, we illustrate its ability to comprehensively and structurally capture multi-scale disease characteristics alongside pathologists' expertise. Furthermore, we validate its computational utility by demonstrating the feasibility of large-scale automated PathoGraph construction, showing performance improvements in downstream deep learning tasks, and presenting two illustrative use cases that highlight its clinical potential. We believe PathoGraph opens new avenues for AI-driven advances in the field of pathology.

Indexed as

NeoplasmsPathologyDeep LearningHumans

Identifiers

PMID40425649
PMCPMC12117166

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.