Evidence map›Paper›PMID 40425507›Full record

ArticleJournal of proteome research2025

Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability.

Gabin Drouard, Fiona A Hagenbeek, Miina Ollikainen, Zhili Zheng, Xiaoling Wang, FinnGen, Samuli Ripatti, Matti Pirinen, Jaakko Kaprio

Abstract readTwin Study
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Proteogenomics in human populations.Nature reviews. Genetics · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A proteomic signature of healthspan.medRxiv : the preprint server for health sciences · 2025
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabin DrouardInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0002-3227-8483
Fiona A HagenbeekInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Miina OllikainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Zhili ZhengBroad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Xiaoling WangGeorgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia 30912, United States.
FinnGenA complete list of the members of the FinnGen banner can be found in the Acknowledgements section.
Samuli RipattiInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Matti PirinenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessing how much variability in blood plasma proteins is due to genetic or environmental factors is essential for advancing personalized medicine. While large-scale studies have established SNP-based heritability (SNP-h

Indexed as

Blood ProteinsPolymorphism, Single NucleotideAgedFemaleHumansMaleMiddle AgedModels, GeneticPhenotypeProteomicsTwinsTwins, MonozygoticBlood Proteinsheritabilitymissing heritabilityproteinstwin modeling

Identifiers

PMID40425507
PMCPMC12150308

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.