ArticleAngewandte Chemie (International ed. in English)2025
Deconstructive Radical-Radical Coupling for Programmable Remote Acylation.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Deconstructive Radical-Radical Coupling for Programmable Remote Acylation.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dicarbonyl compounds are structural motifs that have been extensively utilized in synthetic chemistry, and their downstream transformations have proven valuable in synthesizing numerous heterocycles. Conventional methods for accessing such compounds include the Stetter reaction, the Michael reaction, and Friedel-Crafts acylation. However, a flexible and enabling platform for obtaining all types of 1,n-dicarbonyls remains undeveloped. Reported herein is a unified approach to access a variety of 1,n-dicarbonyls through a radical-promoted deconstructive process utilizing dual photocatalysis/carbene catalysis. The utility of this strategy is demonstrated with a broad scope with robust functional group tolerance along with application in the preparation of γ-amino esters, three-component manifolds, and the first enantioselective deconstructive synthesis of 1,5-dicarbonyls using a chiral NHC catalyst.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.