Evidence map›Paper›PMID 40425489›Full record

ArticleOrthopaedic surgery2025

Comprehensive Impact of Multiplanar Malalignment on Prosthetic Mechanics Under Gait Loading After Total Knee Arthroplasty-A Finite Element Analysis.

Yichao Luan, Min Zhang, Xiang Dong, Hongping Duan, Zhiwei Wang, Zhichang Li, Cheng-Kung Cheng

Abstract read
In one paragraph

Article in Orthopaedic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. [Finite element analysis of tibial and femoral resection configurations on varus alignment in total knee arthroplasty].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yichao LuanSchool of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Min ZhangSchool of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Xiang DongBeijing Naton Medical Research Institute Co., Ltd, Beijing, China.
Hongping DuanBeijing Medical Implant Engineering Research Center, Beijing Naton Technology Group Co., Ltd, Beijing, China.
Zhiwei WangDepartment of Orthopaedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Zhichang LiArthritis Clinical and Research Center, Peking University People's Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-0007-999X
Cheng-Kung ChengSchool of Biomedical Engineering, Shanghai Jiao Tong University, Engineering Research Center of Digital Medicine, Ministry of Education, Shanghai, China.ORCID https://orcid.org/0000-0002-2167-6873

Funding

National Key Research and Development Program of China 2016YFC1101904Natural Science Foundation of Beijing Municipality-Haidian Original Innovation Joint Fund L222148
6 · The paper itself

Abstract

backgroundComponent alignment is a key factor influencing clinical outcomes after total knee arthroplasty (TKA). Previous studies have shown that single-plane alignment can significantly affect knee joint kinematics and biomechanics. However, the comprehensive impact of multiplanar malalignment has been rarely investigated.

objectiveThis study aimed to investigate the influence of the multiplanar malalignment combination on the polyethylene tibial liners under gait loading, a primary activity of daily life, as well as the degree of the influence of the alignments on the different planes.

methodA validated finite element model of a cruciate-retaining knee prosthesis under gait loading was used in this study. Five alignment parameters (-5°, -3°, 0°, 3°, 5°) on each plane (coronal, sagittal, and transverse) were selected to simulate clinical alignment errors, resulting in 125 models combining various alignment errors across the three planes. Boundary and loading conditions were set according to ISO 14243-3:2014. The maximum von Mises stress and contact stress during a gait cycle were recorded for statistical analysis. A polynomial model was used for regression analysis, with the degree of influence of each alignment error on von Mises and contact stress determined by examining the quadratic coefficients.

resultsThe highest Mises and contact stress values occurred with alignment errors of 5° varus, 5° flexion, and 5° internal rotation on the coronal, sagittal, and transverse planes, respectively. The lowest stress values were observed with a combination of 3° valgus, 5° flexion, and 0° internal rotation. The regression analysis yielded an R

conclusionThe coronal alignment of the lower limb has the most significant impact on both Mises stress and contact stress of the tibial liner, followed by the rotational alignment of the tibial component. In contrast, the sagittal alignment of the femoral component has the least influence.

Indexed as

Arthroplasty, Replacement, KneeBone MalalignmentGaitKnee ProsthesisBiomechanical PhenomenaFinite Element AnalysisHumansKnee JointProsthesis DesignWeight-Bearingfinite element analysisgait loadingmultiplanar malalignmentprosthetic mechanicstotal knee arthroplasty

Identifiers

PMID40425489
PMCPMC12214403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.