Evidence map›Paper›PMID 40425487›Full record

ArticleThe Gerontologist2025

Cohort Changes in Cognitive Function Among Mexican Older Adults from 2001 to 2021.

Julián Ponce, Hiram Beltrán-Sánchez

Abstract read
In one paragraph

Article in The Gerontologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Julián PonceDepartment of Community Health Sciences, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, California, USA.
Hiram Beltrán-SánchezDepartment of Community Health Sciences, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, California, USA.ORCID 0000-0002-8334-6191

Funding

The Mexican Health and Aging Study - IIR01AG018016 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Rebeca Wong · 1999 to 2026
$22.6M
USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE · 1999 to 2026
$17.9M
Statistics and Methods CoreR24HD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HANDCOCK, MARK STEPHEN · 2001 to 2016
$10.1M
Health of Aging Mexicans on Both Sides of the BorderR01AG068392 · NIA · UNIVERSITY OF TEXAS SAN ANTONIO · PI RIOSMENA, FERNANDO · 2021 to 2025
$2.2M
National Institute of Child Health and Human Development P2C-HD041022NIA NIH HHS P30 AG017265NIA NIH HHS R01 AG018016NIA NIH HHS R01 AG068392NIA NIH HHS R01AG068392 and R01AG018016NICHD NIH HHS R24 HD041022
6 · The paper itself

Abstract

BACKGROUND AND

objectivesMultimorbidity (2+ chronic conditions) associated with faster cognitive decline among older adults, yet longitudinal evidence from low- and middle-income countries, including Mexico, remains limited. This study examines cohort differences in the annual rate of cognitive decline, measured by global cognitive function scores (GCFS), and tests whether the association between multimorbidity and cognitive decline differs between two cohorts aged 50-60 in 2001 and 2012. RESEARCH DESIGN AND

methodsWe assess two 10-year birth cohorts (Cohort 1: born 1941-1951, n = 5,345 Cohort 2: born 1952-1962, n = 4,378), at 3 time points (Cohort 1: 2001, 2003, and 2012; Cohort 2: 2012, 2015, 2021), at ages 50-60 at baseline. We examine cohort differences in average annual GCFS changes by fitting growth curve models incorporating random intercepts and slopes.

resultsTwo key findings emerged. First, the earlier cohort (Cohort 1, 2001), experienced a faster average annual rate of decline in GCFS than the recent cohort (Cohort 2, 2012). Second, the link between multimorbidity and cognitive decline did not significantly differ between cohorts net of possible confounders. DISCUSSION AND IMPLICATIONS: Our findings advance our understanding of cohort differences in cognitive decline and how the influence of multimorbidity on cognitive decline has evolved in Mexico. The slower rate of decline among the recent cohort suggests potential improvements in cognitive reserve due to educational improvements. Improvements in healthcare access over the past decades may have mitigated the negative consequences of multimorbidity on cognitive decline, potentially explaining the absence of cohort differences.

Indexed as

CognitionCognitive DysfunctionAgedCohort StudiesFemaleHumansLongitudinal StudiesMaleMexicoMiddle AgedMultimorbidityCognitive declineMexicoMultimorbidity

Identifiers

PMID40425487
PMCPMC12284392

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.